公开(公告)号：US20170204158A1

公开(公告)日：2017-07-20

申请号：US15463910

申请日：2017-03-20

申请人： Andrew J. Murphy ,  Nicholas J. Papadopoulos ,  Jamie M Orengo

发明人： Andrew J. Murphy ,  Nicholas J. Papadopoulos ,  Jamie M Orengo

IPC分类号： C07K14/715 ,  A61K39/395 ,  A61K45/06

CPC分类号： C07K14/7155 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/735

摘要： The present invention provides interleukin-33 (IL-33) antagonists comprising one or more IL-33-binding domains and one or more multimerizing domains and methods of using the same. According to certain embodiments of the invention, the IL-33-binding domains can comprise an IL-33-binding portion of an ST2 protein and/or an extracellular portion of an IL-1RAcP protein. The IL-33 antagonists of the invention are useful for the treatment of diseases and disorders associated with IL-33 signaling and/or IL-33 cellular expression, such as infectious diseases, inflammatory diseases, allergic diseases and fibrotic diseases.