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    MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF
    1.
    发明申请
    MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF 有权
    5-HT受体的调节剂及其使用方法

    公开(公告)号：US20110130382A1

    公开(公告)日：2011-06-02

    申请号：US12909319

    申请日：2010-10-21

    Applicant: Ying Wang ,  Jason T. Brewer ,  Irini Akritopoulou-Zanze ,  Stevan W. Djuric ,  Frauke Pohlki ,  Wilfried Braje ,  Ana-Lucia Relo

    Inventor： Ying Wang ,  Jason T. Brewer ,  Irini Akritopoulou-Zanze ,  Stevan W. Djuric ,  Frauke Pohlki ,  Wilfried Braje ,  Ana-Lucia Relo

    IPC: A61K31/551 ,  C07D487/04 ,  A61P25/00 ,  A61K31/55 ,  A61P3/04 ,  A61P3/10 ,  A61P17/06 ,  A61P27/02 ,  A61P15/10

    CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D498/04

    Abstract: The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

    Abstract translation: 本申请涉及1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1,4]苯并二氮杂，1,2,3,4,4a， 7-八氢吡嗪并[1,2-a] [1,5]苯并二氮杂，2,3,4,4a，5,6,7,11b-八氢-1H-吡啶并[3,4-d] [2]苯并氮杂， 1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1]苯并氮杂，1,2,3,4,4a，5-六氢-7H-吡嗪并[1,2 -a] [4,1]苯并氧氮杂和2,3,4,4a，5,6-六氢-1H-吡嗪并[2,1-d] [1,5]苯并氧氮杂和5,6,7,7a ，其中R 1，R 2，R 3，R 4，R 5，R 6，R 6，R 5，R 6， X1，X2，X3，X4，Y1，Y2和Y3如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

    Modulators of 5-HT receptors and methods of use thereof
    2.
    发明授权
    Modulators of 5-HT receptors and methods of use thereof 有权
    5-HT受体的调节剂及其使用方法

    公开(公告)号：US08546377B2

    公开(公告)日：2013-10-01

    申请号：US12909319

    申请日：2010-10-21

    Applicant: Ying Wang ,  Jason T. Brewer ,  Irini Akritopoulou-Zanze ,  Stevan W. Djuric ,  Frauke Pohlki ,  Wilfried Braje ,  Ana-Lucia Relo

    Inventor： Ying Wang ,  Jason T. Brewer ,  Irini Akritopoulou-Zanze ,  Stevan W. Djuric ,  Frauke Pohlki ,  Wilfried Braje ,  Ana-Lucia Relo

    IPC: C07D515/00 ,  A61K31/553 ,  A61P25/00

    CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D498/04

    Abstract: The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

    Abstract translation: 本申请涉及1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1,4]苯并二氮杂，1,2,3,4,4a， 7-八氢吡嗪并[1,2-a] [1,5]苯并二氮杂，2,3,4,4a，5,6,7,11b-八氢-1H-吡啶并[3,4-d] [2]苯并氮杂， 1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1]苯并氮杂，1,2,3,4,4a，5-六氢-7H-吡嗪并[1,2 -a] [4,1]苯并氧氮杂和2,3,4,4a，5,6-六氢-1H-吡嗪并[2,1-d] [1,5]苯并氧氮杂和5,6,7,7a ，其中R 1，R 2，R 3，R 4，R 5，R 6，R 6，R 5，R 6， X1，X2，X3，X4，Y1，Y2和Y3如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

    Modulators of 5-HT receptors and methods of use thereof
    3.
    发明授权
    Modulators of 5-HT receptors and methods of use thereof 有权
    5-HT受体的调节剂及其使用方法

    公开(公告)号：US08518933B2

    公开(公告)日：2013-08-27

    申请号：US12765034

    申请日：2010-04-22

    Applicant: Ying Wang ,  Jason T. Brewer ,  Irini Akritopoulou-Zanze ,  Stevan W. Djuric ,  Bhadra Shelat ,  Frauke Pohlki ,  Wilfried Braje ,  Ana-Lucia Relo

    Inventor： Ying Wang ,  Jason T. Brewer ,  Irini Akritopoulou-Zanze ,  Stevan W. Djuric ,  Bhadra Shelat ,  Frauke Pohlki ,  Wilfried Braje ,  Ana-Lucia Relo

    IPC: C07D515/00 ,  A61K31/553 ,  A61P25/00

    CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D471/14 ,  C07D487/14 ,  C07D491/04 ,  C07D498/04 ,  Y02E60/321

    Abstract: The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2 -a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7 -octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2 -a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

    Abstract translation: 本申请涉及1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1,4]苯并二氮杂，1,2,3,4,4a， 7-八氢吡嗪并[1,2-a] [1,5]苯并二氮杂，2,3,4,4a，5,6,7,11b-八氢-1H-吡啶并[3,4-d] [2]苯并氮杂， 1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1]苯并氮杂，1,2,3,4,4a，5-六氢-7H-吡嗪并[1,2 -a] [4,1]苯并氧氮杂和2,3,4,4a，5,6-六氢-1H-吡嗪并[2,1-d] [1,5]苯并氧氮杂和5,6,7,7a ，其中R 1，R 2，R 3，R 4，R 5，R 6，R 6，R 5，R 6， X1，X2，X3，X4，Y1，Y2和Y3如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

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