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公开(公告)号:US08182816B2
公开(公告)日:2012-05-22
申请号:US12944338
申请日:2010-11-11
申请人: Francisco Sanchez-Madrid , Carlos-Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gomez
发明人: Francisco Sanchez-Madrid , Carlos-Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gomez
IPC分类号: A61K39/395
CPC分类号: C07K16/2851 , A61K2039/505 , C07K2317/76
摘要: Disclosed are methods of treating subjects having cancers including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antibodies specific to the early activation molecules, and methods of use, are also disclosed.
摘要翻译: 公开了治疗患有癌症的受试者的方法,包括向受试者施用有效量的早期活化分子激动剂,拮抗剂或抑制剂。 还公开了对早期活化分子特异性的人单克隆抗体及其使用方法。
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公开(公告)号:US07867475B2
公开(公告)日:2011-01-11
申请号:US10770639
申请日:2004-02-02
申请人: Francisco Sanchez-Madrid , Carlos Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gómez
发明人: Francisco Sanchez-Madrid , Carlos Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gómez
IPC分类号: A61K51/00
CPC分类号: C07K16/2851 , A61K2039/505 , C07K2317/76
摘要: Disclosed are methods of treating subjects having disorders or conditions characterized by an unwanted immune response including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antibodies specific to the early activation molecules, and methods of use, are also disclosed.
摘要翻译: 公开了治疗具有由不想要的免疫应答表征的疾病或病症的受试者的方法,包括向受试者施用有效量的早期活化分子激动剂,拮抗剂或抑制剂。 还公开了对早期活化分子特异性的人单克隆抗体及其使用方法。
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公开(公告)号:US20110081292A1
公开(公告)日:2011-04-07
申请号:US12944432
申请日:2010-11-11
申请人: Francisco Sanchez-Madrid , Carlos-Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gómez
发明人: Francisco Sanchez-Madrid , Carlos-Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gómez
IPC分类号: A61K51/10 , A61K39/395 , A61P31/14
CPC分类号: C07K16/2851 , A61K2039/505 , C07K2317/76
摘要: Disclosed are methods of treating viral hepatitis including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antibodies specific to the early activation molecules, and methods of use, are also disclosed.
摘要翻译: 公开了治疗病毒性肝炎的方法,包括向受试者施用有效量的早期活化分子激动剂,拮抗剂或deputor。 还公开了对早期活化分子特异性的人单克隆抗体及其使用方法。
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公开(公告)号:US20110165071A1
公开(公告)日:2011-07-07
申请号:US12944338
申请日:2010-11-11
申请人: Francisco Sanchez-Madrid , Carlos Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gómez
发明人: Francisco Sanchez-Madrid , Carlos Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gómez
IPC分类号: A61K39/395 , A61K51/00 , A61P35/00
CPC分类号: C07K16/2851 , A61K2039/505 , C07K2317/76
摘要: Disclosed are methods of treating subjects having cancers including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antibodies specific to the early activation molecules, and methods of use, are also disclosed.
摘要翻译: 公开了治疗患有癌症的受试者的方法,包括向受试者施用有效量的早期活化分子激动剂,拮抗剂或抑制剂。 还公开了对早期活化分子特异性的人单克隆抗体及其使用方法。
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