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    Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins
    1.
    发明申请
    Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins 审中-公开
    使用结核分枝杆菌编码序列促进异源蛋白质的稳定和高产量表达的方法

    公开(公告)号：US20060040356A1

    公开(公告)日：2006-02-23

    申请号：US11222451

    申请日：2005-09-07

    申请人： Yasir Skeiky ,  Jeffrey Guderian

    发明人： Yasir Skeiky ,  Jeffrey Guderian

    IPC分类号： C12P21/06 ,  C07H21/04 ,  C12N15/74 ,  C12N1/21 ,  C07K14/35

    CPC分类号： C07K14/35 ,  C07K14/4721 ,  C07K2319/00

    摘要： The present invention relates generally to nucleic acid and amino acid sequences of a fusion polypeptide comprising a Mycobacterium tuberculosis polypeptide, and a heterologous polypeptide of interest, expression vectors and host cells comprising such nucleic acids, and methods for producing such fusion polypeptides. In particular, the invention relates to materials and methods of using such M. tuberculosis sequence as a fusion partner to facilitate the stable and high yield expression of recombinant heterologous polypeptides of both eukaryotic and prokaryotic origin.

    摘要翻译： 本发明一般涉及包含结核分枝杆菌多肽，感兴趣的异源多肽，表达载体和包含这种核酸的宿主细胞的融合多肽的核酸和氨基酸序列，以及用于产生这种融合多肽的方法。 特别地，本发明涉及使用这种结核分枝杆菌序列作为融合配偶体以促进真核和原核来源的重组异源多肽的稳定和高产量表达的材料和方法。