公开(公告)号：US20120251514A1

公开(公告)日：2012-10-04

申请号：US13509476

申请日：2010-11-12

申请人： Daniel Fowler ,  Shoba Amarnath ,  Jeffrey Medin ,  James Chian Ming Wang

发明人： Daniel Fowler ,  Shoba Amarnath ,  Jeffrey Medin ,  James Chian Ming Wang

IPC分类号： A61K31/7088 ,  C12N15/867 ,  C12N5/10 ,  C12N1/15 ,  A61P37/06 ,  C12N1/21 ,  C12N1/11 ,  C12N15/62 ,  A61K35/14 ,  C12N15/63 ,  C12N1/13

CPC分类号： C12N9/1229 ,  C07K14/70503 ,  C07K14/70532

摘要： The invention provides nucleic acids comprising a nucleotide sequence encoding programmed death ligand-1 (PD-L1) and a nucleotide sequence encoding a fusion protein comprising thymidylate kinase (TMPK) or a variant thereof and a cell surface marker or a variant thereof. Recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and kits relating to the nucleic acids are disclosed. Methods of treating or preventing a disease in a host and methods of suppressing an immune system in a host are also disclosed.

摘要翻译： 本发明提供了包含编码程序性死亡配体-1（PD-L1）的核苷酸序列和编码包含胸苷酸激酶（TMPK）或其变体和细胞表面标记或其变体的融合蛋白的核苷酸序列的核酸。 公开了重组表达载体，宿主细胞，细胞群，药物组合物和与核酸有关的试剂盒。 还公开了治疗或预防宿主疾病的方法和抑制宿主免疫系统的方法。