-
1.发明授权BAB-type tri-block copolymer comprising polylactic acid (A) and polyethylene glycol (B), method for producing same, and drug delivery system using same 有权包含聚乳酸（A）和聚乙二醇（B）的BAB型三嵌段共聚物，其制备方法和使用其的药物递送系统公开(公告)号：US09125944B2
公开(公告)日：2015-09-08
申请号：US14343862
申请日：2011-10-31
Applicant: Kyung Taek Oh , Jeong Min Yun
Inventor： Kyung Taek Oh , Jeong Min Yun
CPC classification number: A61K47/34 , A61K9/1075 , C08G63/664 , C08G65/08 , C08G65/332 , C08G81/00 , C08L2203/02
Abstract: Provided are a BAB-type tri-block copolymer including a polylactic acid (A) that is a hydrophobic block and polyethylene glycol (B) that is a hydrophilic block, a method of preparing the BAB-type tri-block copolymer including synthesizing a polylactic acid (A)-polyethylene glycol (B) di-block copolymer by a ring opening polymerization of a lactic acid monomer using a hydroxyl group of polyethylene glycol (B) as a polymerization initiator; and synthesizing a BAB-type tri-block copolymer by reacting the AB-type di-block copolymer with polyethylene glycol (B) including at least one carboxyl group at one or more terminals thereof in the presence of a coupling agent and a catalyst, and a drug delivery system using the BAB-type tri-block copolymer.
Abstract translation: 提供了包含作为亲水性嵌段的疏水性嵌段的聚乳酸（A）和聚乙二醇（B）的BAB型三嵌段共聚物，制备BAB型三嵌段共聚物的方法，包括合成聚乳酸 通过使用聚乙二醇（B）的羟基作为聚合引发剂的乳酸单体的开环聚合来制备酸（A） - 聚乙二醇（B）二嵌段共聚物; 并通过使AB型二嵌段共聚物与其一端或多端含有至少一个羧基的聚乙二醇（B）在偶联剂和催化剂存在下反应合成BAB型三嵌段共聚物，以及 使用BAB型三嵌段共聚物的药物递送系统。
-
2.发明申请BAB-TYPE TRI-BLOCK COPOLYMER COMPRISING POLYLACTIC ACID (A) AND POLYETHYLENE GLYCOL (B), METHOD FOR PRODUCING SAME, AND DRUG DELIVERY SYSTEM USING SAME 有权包含聚乳酸（A）和聚乙烯甘油（B）的BAB型三嵌段共聚物，其制备方法和使用其的药物递送系统公开(公告)号：US20140205638A1
公开(公告)日：2014-07-24
申请号：US14343862
申请日：2011-10-31
Applicant: Kyung Taek Oh , Jeong Min Yun
Inventor： Kyung Taek Oh , Jeong Min Yun
CPC classification number: A61K47/34 , A61K9/1075 , C08G63/664 , C08G65/08 , C08G65/332 , C08G81/00 , C08L2203/02
Abstract: Provided are a BAB-type tri-block copolymer including a polylactic acid (A) that is a hydrophobic block and polyethylene glycol (B) that is a hydrophilic block, a method of preparing the BAB-type tri-block copolymer including synthesizing a polylactic acid (A)-polyethylene glycol (B) di-block copolymer by a ring opening polymerization of a lactic acid monomer using a hydroxyl group of polyethylene glycol (B) as a polymerization initiator; and synthesizing a BAB-type tri-block copolymer by reacting the AB-type di-block copolymer with polyethylene glycol (B) including at least one carboxyl group at one or more terminals thereof in the presence of a coupling agent and a catalyst, and a drug delivery system using the BAB-type tri-block copolymer.
Abstract translation: 提供了包含作为亲水性嵌段的疏水性嵌段的聚乳酸（A）和聚乙二醇（B）的BAB型三嵌段共聚物，制备BAB型三嵌段共聚物的方法，包括合成聚乳酸 通过使用聚乙二醇（B）的羟基作为聚合引发剂的乳酸单体的开环聚合来制备酸（A） - 聚乙二醇（B）二嵌段共聚物; 并通过使AB型二嵌段共聚物与其一端或多端含有至少一个羧基的聚乙二醇（B）在偶联剂和催化剂存在下反应合成BAB型三嵌段共聚物，以及 使用BAB型三嵌段共聚物的药物递送系统。
-
Search Results
2
records
(took 0.012 seconds)
