公开(公告)号：US09371305B2

公开(公告)日：2016-06-21

申请号：US14401600

申请日：2012-08-10

申请人： Yanmei Zhang ,  John Jeffrey Talley ,  Mark G. Obukowicz ,  Zhengchao Tu ,  Micky Tortorella ,  Yican Wang ,  Jianqi Liu ,  Yan Chen ,  Xiaorong Liu ,  Xin Lu

发明人： Yanmei Zhang ,  John Jeffrey Talley ,  Mark G. Obukowicz ,  Zhengchao Tu ,  Micky Tortorella ,  Yican Wang ,  Jianqi Liu ,  Yan Chen ,  Xiaorong Liu ,  Xin Lu

IPC分类号： C07D311/58

CPC分类号： A61K31/353 ,  A61K31/382 ,  A61K31/47 ,  C07D311/58

摘要： The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.

摘要翻译： 本发明公开了具有式（I）所示结构特征的氘代苯并吡喃化合物或其药学上可接受的盐或立体异构体或其前药分子。 具有优异的抗炎和镇痛作用和抑制肿瘤细胞生长的能力，这些化合物是新型的COX-2选择性抑制剂。 本申请公开的化合物及其药学上可接受的盐可用于制备用于治疗或预防肿瘤的抗炎和镇痛药物和药物。

公开(公告)号：US20150133538A1

公开(公告)日：2015-05-14

申请号：US14401600

申请日：2012-08-10

申请人： Yanmei Zhang ,  John Jeffrey Talley ,  Mark G. Obukowicz ,  Zhengchao Tu ,  Micky Tortorella ,  Yican Wang ,  Jianqi Liu ,  Yan Chen ,  Xiaorong Liu ,  Xin Lu

发明人： Yanmei Zhang ,  John Jeffrey Talley ,  Mark G. Obukowicz ,  Zhengchao Tu ,  Micky Tortorella ,  Yican Wang ,  Jianqi Liu ,  Yan Chen ,  Xiaorong Liu ,  Xin Lu

IPC分类号： C07D311/58

CPC分类号： A61K31/353 ,  A61K31/382 ,  A61K31/47 ,  C07D311/58

摘要： The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.

摘要翻译： 本发明公开了具有式（I）所示结构特征的氘代苯并吡喃化合物或其药学上可接受的盐或立体异构体或其前药分子。 具有优异的抗炎和镇痛作用和抑制肿瘤细胞生长的能力，这些化合物是新型的COX-2选择性抑制剂。 本申请公开的化合物及其药学上可接受的盐可用于制备用于治疗或预防肿瘤的抗炎和镇痛药物和药物。