公开(公告)号：US07094948B2

公开(公告)日：2006-08-22

申请号：US10493943

申请日：2002-11-13

申请人： Akira Miyake ,  Yukihiro Nakamura ,  Jianwei Ni ,  Shinobu Mochizuki

发明人： Akira Miyake ,  Yukihiro Nakamura ,  Jianwei Ni ,  Shinobu Mochizuki

IPC分类号： A01K67/027

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  C07K14/705 ,  C12N15/8509 ,  C12N2830/008

摘要： There is discloses a transgenic mouse over-expressing a potassium channel BEC1, which can be used as an effective tool for screening a substance for antidementia or a substance to improve learning and memory.Also disclosed are an in vivo screening method of a substance for antidementia or a substance to improve learning and memory, which uses the learning and memory abilities of said mouse as the index, and an in vivo screening of a substance for antianxiety, which uses acceleration of anxiety as the index.In addition, there is disclosed a method for producing a pharmaceutical composition for antidementia, learning and memory improvement use or antianxiety, using a substance capable of inhibiting the learning and memory potassium channel activity as the active ingredient which can be obtained by the aforementioned screening method of the present invention.

摘要翻译： 公开了一种过表达钾通道BEC1的转基因小鼠，其可以用作筛选用于抗痴呆的物质的有效工具或改善学习和记忆的物质。 还公开了用于抗痴呆的物质的体内筛选方法或改善学习和记忆的物质，其使用所述小鼠的学习和记忆能力作为指标，并且对使用加速度的抗焦虑物质进行体内筛选 的焦虑作为指标。 此外，公开了使用能够抑制学习和记忆钾通道活性的物质作为活性成分的能够通过上述筛选方法获得的抗痴呆，学习和记忆改善用途或抗焦虑药物组合物的制备方法 的本发明。