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1.发明申请COMPLEX OF CELL TRANSLOCATIONAL PEPTIDE AND MAGNETIC NANOPARTICLES AND USE THEREOF 审中-公开细胞转移肽和磁性纳米颗粒的复合物及其用途公开(公告)号：US20100298536A1
公开(公告)日：2010-11-25
申请号：US12681027
申请日：2008-10-02
CPC分类号： A61K49/1866 , A61K49/0041 , A61K49/0043 , A61K49/0093 , A61K49/085 , A61K49/14 , B82Y5/00
摘要： The present invention relates to a cell-penetrating peptide/fluorescence-labeled magnetic nanoparticle complex and the use thereof. More specifically, relates to a cell-penetrating peptide/fluorescence-labeled magnetic nanoparticle complex in which a cell-penetrating peptide is chemically linked to a fluorescence-labeled magnetic nanoparticle, such that fluorescence-labeled magnetic nanoparticle can be stably introduced directly into cells without endocytosis, and a composition for cell imaging containing the complex. The disclosed invention suggests an innovative therapeutic technology which shows high stability, maximizes the effect of imaging diagnosis through optimal targeting and minimizes side effects, unlike existing viral peptide transporters.
摘要翻译： 本发明涉及细胞穿透肽/荧光标记的磁性纳米颗粒复合物及其用途。 更具体地，涉及细胞穿透肽/荧光标记的磁性纳米颗粒复合物，其中细胞穿透肽与荧光标记的磁性纳米颗粒化学连接，使得荧光标记的磁性纳米颗粒可以直接稳定地引入到细胞中而没有 内吞作用，以及含有该复合物的细胞成像用组合物。 所公开的发明提出了一种创新的治疗技术，其显示出高稳定性，与现有的病毒肽转运蛋白不同，通过最佳靶向使得成像诊断的效果最大化并且最小化副作用。
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公开(公告)号：US09023987B2
公开(公告)日：2015-05-05
申请号：US13821790
申请日：2011-04-25
CPC分类号： C07K14/435 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/51
摘要： The present invention relates to a novel human-derived cell permeable peptide-bioactive peptide conjugate and the use thereof. According to the present invention, cationic cell permeable peptides derived from human bone morphogenetic protein-4 have no toxicity and immunogenicity and thus exhibit high stability as compared to viral peptide delivery vehicles, and can transport cell impermeable material into cells and into an organism without any damage to cell or material, thereby significantly increasing target gene expression. In addition, the peptide may be applied to clinical use without having to undergo a large number of processes and mass-produced, such that the present invention may be useful in the development of a drug delivery system and treatment technologies using said peptide.
摘要翻译： 本发明涉及新型人源细胞可渗透肽 - 生物活性肽缀合物及其用途。 根据本发明，衍生自人骨形态发生蛋白-4的阳离子细胞可渗透肽没有毒性和免疫原性，因此与病毒肽递送载体相比表现出高稳定性，并且可以将细胞不可渗透的材料输送到细胞中并进入生物体 破坏细胞或物质，从而显着增加靶基因表达。 此外，该肽可以应用于临床用途，而不必经历大量的方法和批量生产，使得本发明可用于开发药物递送系统和使用所述肽的治疗技术。
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3.发明申请HUMAN-DERIVED CELL-PERMEABLE PEPTIDE BIOACTIVE PEPTIDE CONJUGATE, AND USE THEREOF 有权人源细胞渗透肽生物活性肽结合物及其用途公开(公告)号：US20130237484A1
公开(公告)日：2013-09-12
申请号：US13821790
申请日：2011-04-25
IPC分类号： C07K14/435 , C07K7/08 , C07K7/06
CPC分类号： C07K14/435 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/51
摘要： The present invention relates to a novel human-derived cell permeable peptide-bioactive peptide conjugate and the use thereof.According to the present invention, cationic cell permeable peptides derived from human bone morphogenetic protein-4 have no toxicity and immuno-genicity and thus exhibit high stability as compared to viral peptide delivery vehicles, and can transport cell impermeable material into cells and into an organism without any damage to cell or material, thereby significantly increasing target gene expression. In addition, the peptide may be applied to clinical use without having to undergo a large number of processes and mass-produced, such that the present invention may be useful in the development of a drug delivery system and treatment technologies using said peptide.
摘要翻译： 本发明涉及新型人源细胞可渗透肽 - 生物活性肽缀合物及其用途。 根据本发明，衍生自人骨形态发生蛋白-4的阳离子细胞渗透肽没有毒性和免疫原性，因此与病毒肽递送载体相比表现出高稳定性，并且可以将细胞不可渗透的材料转运到细胞中并进入生物体 对细胞或物质没有任何损害，从而显着增加靶基因表达。 此外，该肽可以应用于临床用途，而不必经历大量的方法和批量生产，使得本发明可用于开发药物递送系统和使用所述肽的治疗技术。
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