METHODS OF ADMINISTERING ANTI-TNFalpha ANTIBODIES
    1.
    发明申请
    METHODS OF ADMINISTERING ANTI-TNFalpha ANTIBODIES 审中-公开
    施用抗TNFα抗体的方法

    公开(公告)号:US20120177596A1

    公开(公告)日:2012-07-12

    申请号:US13288299

    申请日:2011-11-03

    摘要: Methods of treating disorders in which TFNα activity is detrimental via biweekly, subcutaneous administration of human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. The antibody may be administered with or without methotrexate. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize hTNFα activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Kits containing a pharmaceutical composition and instructions for dosing, and preloaded syringes containing pharmaceutical compositions are also encompassed by the invention.

    摘要翻译: 公开了通过每两周一次皮下施用特异性结合人肿瘤坏死因子α(hTNFα)的人抗体(优选重组人抗体)治疗TFNα活性有害的疾病的方法。 抗体可以与或不与甲氨蝶呤一起施用。 这些抗体对hTNFα具有高亲和力(例如,Kd = 10-8M或更低),hTNFα解离的缓慢速率(例如,Koff = 10-3秒-1或更低),并在体外和体内中和hTNFα活性 。 本发明的抗体可以是全长抗体或其抗原结合部分。 包含药物组合物和用于给药的说明书和含有药物组合物的预装注射器的试剂盒也包括在本发明中。

    Methods of administering anti-TNFα antibodies
    4.
    发明授权
    Methods of administering anti-TNFα antibodies 有权
    施用抗TNFα抗体的方法

    公开(公告)号:US08889135B2

    公开(公告)日:2014-11-18

    申请号:US10163657

    申请日:2002-06-05

    摘要: Methods of treating disorders in which TFNα activity is detrimental via biweekly, subcutaneous administration of human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. The antibody may be administered with or without methotrexate. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize hTNFα activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Kits containing a pharmaceutical composition and instructions for dosing, and preloaded syringes containing pharmaceutical compositions are also encompassed by the invention.

    摘要翻译: 公开了通过每两周一次皮下施用特异性结合人肿瘤坏死因子α(hTNFα)的人抗体(优选重组人抗体)治疗TFNα活性有害的疾病的方法。 抗体可以与或不与甲氨蝶呤一起施用。 这些抗体对hTNFα具有高亲和力(例如,Kd = 10-8M或更低),hTNFα解离的缓慢速率(例如,Koff = 10-3秒-1或更低),并在体外和体内中和hTNFα活性 。 本发明的抗体可以是全长抗体或其抗原结合部分。 包含药物组合物和用于给药的说明书和含有药物组合物的预装注射器的试剂盒也包括在本发明中。

    METHODS OF ADMINISTERING ANTI-TNFalpha ANTIBODIES
    6.
    发明申请
    METHODS OF ADMINISTERING ANTI-TNFalpha ANTIBODIES 审中-公开
    施用抗TNFα抗体的方法

    公开(公告)号:US20130004507A1

    公开(公告)日:2013-01-03

    申请号:US13530363

    申请日:2012-06-22

    摘要: Methods of treating disorders in which TFNα activity is detrimental via biweekly, subcutaneous administration of human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. The antibody may be administered with or without methotrexate. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize hTNFα activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Kits containing a pharmaceutical composition and instructions for dosing, and preloaded syringes containing pharmaceutical compositions are also encompassed by the invention.

    摘要翻译: 公开了通过每两周一次皮下施用特异性结合人肿瘤坏死因子α(hTNFα)的人抗体(优选重组人抗体)治疗TFNα活性有害的疾病的方法。 抗体可以与或不与甲氨蝶呤一起施用。 这些抗体对hTNFα具有高亲和力(例如,Kd = 10-8M或更低),hTNFα解离的缓慢速率(例如,Koff = 10-3秒-1或更低),并在体外和体内中和hTNFα活性 。 本发明的抗体可以是全长抗体或其抗原结合部分。 包含药物组合物和用于给药的说明书和含有药物组合物的预装注射器的试剂盒也包括在本发明中。