公开(公告)号：US20130310681A1

公开(公告)日：2013-11-21

申请号：US13950811

申请日：2013-07-25

申请人： Volkmar SCHULZ ,  Torsten SOLF ,  Johan OVERWEG ,  Andreas THON

发明人： Volkmar SCHULZ ,  Torsten SOLF ,  Johan OVERWEG ,  Andreas THON

IPC分类号： G01R33/48

CPC分类号： A61B5/0035 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  G01R33/481 ,  G01T1/1603

摘要： In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

摘要翻译： 在组合系统中，磁共振（MR）扫描器包括配置成至少在从其获取MR数据的MR检查区域中产生静态磁场的磁体。 辐射检测器被配置为检测在正电子发射断层摄影（PET）检查区域中由正电子 - 电子湮灭事件产生的γ射线。 辐射检测器包括电子加速器元件，其具有基本上平行于或与静磁场平行的电子加速度方向。 在一些实施例中，磁体是具有设置在磁共振检查区域的相对侧上的第一和第二间隔开的磁极片的开放磁体，并且辐射检测器包括第一和第二辐射检测器阵列，其布置有第一和第二间隔开的 磁极片。

公开(公告)号：US08188736B2

公开(公告)日：2012-05-29

申请号：US12521907

申请日：2008-01-08

申请人： Volkmar Schulz ,  Torsten Solf ,  Johan Overweg ,  Andreas Thon

发明人： Volkmar Schulz ,  Torsten Solf ,  Johan Overweg ,  Andreas Thon

IPC分类号： G01V3/00

CPC分类号： A61B5/0035 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  G01R33/481 ,  G01T1/1603

摘要： In a combined system, a magnetic resonance (MR) scanner includes a magnet (10, 110) configured to generate a static magnetic field (B0) at least in a MR examination region (12) from which MR data are acquired. Radiation detectors (40, 41, 140) are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region (70). The radiation 5 detectors include electron multiplier elements (60, 160) having a direction of electron acceleration (ae) arranged substantially parallel or anti-parallel with the static magnetic field (B0). In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces (14, 15) disposed on opposite sides of a magnetic 10 resonance examination region, and the radiation detectors include first and second arrays (40, 41) of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

摘要翻译： 在组合系统中，磁共振（MR）扫描器包括至少在从其获取MR数据的MR检查区域（12）中产生静态磁场（B0）的磁体（10,110）。 辐射检测器（40,41,140）被配置为检测由正电子发射断层摄影（PET）检查区域（70）中的正电子 - 电子湮灭事件产生的伽马射线。 辐射5检测器包括具有与静态磁场（B0）基本平行或反平行排列的电子加速度（ae）方向的电子倍增器元件（60,160）。 在一些实施例中，磁体是具有设置在磁性10共振检查区域的相对侧上的第一和第二间隔开的磁极片（14,15）的开放磁体，并且辐射检测器包括第一和第二阵列（40,41） 的辐射探测器，其布置有第一和第二间隔开的磁极片。

公开(公告)号：US20090004114A1

公开(公告)日：2009-01-01

申请号：US12096191

申请日：2006-11-15

申请人： Johan Overweg

发明人： Johan Overweg

IPC分类号： A61K49/18 ,  A61K49/06

CPC分类号： A61K49/18 ,  A61K49/0002 ,  A61K49/20

摘要： Systems and methods for monitoring in vivo release of therapeutic and/or diagnostic agents, e.g., drugs, are provided. The disclosed systems and methods use a contrast agent and Overhauser-enhanced nuclear magnetic resonance (NMR) to monitor and/or measure the concentration and distribution of the contrast agent. Provided the contrast agent and the therapeutic/diagnostic agent have similar pharmaco-kinetics, the disclosed system/method may also be used to monitor and/or measure the concentration of such therapeutic/diagnostic agent (e.g., a drug), e.g., in the form of a volume-averaged signal and/or dynamic two-dimensional or three-dimensional images. In exemplary embodiments of the present disclosure, the therapeutic/diagnostic agent and the contrast agent are introduced to the body in an encapsulated form, e.g., within hollow nanoparticles.

摘要翻译： 提供了用于监测体内释放治疗和/或诊断剂例如药物的系统和方法。 所公开的系统和方法使用造影剂和Overhauser增强核磁共振（NMR）来监测和/或测量造影剂的浓度和分布。 如果造影剂和治疗/诊断剂具有相似的药物动力学，则所公开的系统/方法也可用于监测和/或测量此类治疗/诊断剂（例如药物）的浓度，例如在 体积平均信号和/或动态二维或三维图像的形式。 在本公开的示例性实施方案中，将治疗/诊断剂和造影剂以封装形式引入身体，例如在中空纳米颗粒内。

公开(公告)号：US20100102813A1

公开(公告)日：2010-04-29

申请号：US12521907

申请日：2008-01-08

申请人： Volkmar Schulz ,  Torsten Solf ,  Johan Overweg ,  Andreas Thon

发明人： Volkmar Schulz ,  Torsten Solf ,  Johan Overweg ,  Andreas Thon

IPC分类号： G01R33/48 ,  G01R33/44

CPC分类号： A61B5/0035 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  G01R33/481 ,  G01T1/1603

摘要： In a combined system, a magnetic resonance (MR) scanner includes a magnet (10, 110) configured to generate a static magnetic field (B0) at least in a MR examination region (12) from which MR data are acquired. Radiation detectors (40, 41, 140) are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region (70). The radiation 5 detectors include electron multiplier elements (60, 160) having a direction of electron acceleration (ae) arranged substantially parallel or anti-parallel with the static magnetic field (B0). In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces (14, 15) disposed on opposite sides of a magnetic 10 resonance examination region, and the radiation detectors include first and second arrays (40, 41) of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

摘要翻译： 在组合系统中，磁共振（MR）扫描器包括至少在从其获取MR数据的MR检查区域（12）中产生静态磁场（B0）的磁体（10,110）。 辐射检测器（40,41,140）被配置为检测由正电子发射断层摄影（PET）检查区域（70）中的正电子 - 电子湮灭事件产生的伽马射线。 辐射5检测器包括具有与静态磁场（B0）基本平行或反平行排列的电子加速度（ae）方向的电子倍增器元件（60,160）。 在一些实施例中，磁体是具有设置在磁性10共振检查区域的相对侧上的第一和第二间隔开的磁极片（14,15）的开放磁体，并且辐射检测器包括第一和第二阵列（40,41） 的辐射探测器，其布置有第一和第二间隔开的磁极片。

公开(公告)号：US08723521B2

公开(公告)日：2014-05-13

申请号：US13950811

申请日：2013-07-25

申请人： Volkmar Schulz ,  Torsten Solf ,  Johan Overweg ,  Andreas Thon

发明人： Volkmar Schulz ,  Torsten Solf ,  Johan Overweg ,  Andreas Thon

IPC分类号： G01V3/00

CPC分类号： A61B5/0035 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  G01R33/481 ,  G01T1/1603

摘要： In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

摘要翻译： 在组合系统中，磁共振（MR）扫描器包括配置成至少在从其获取MR数据的MR检查区域中产生静态磁场的磁体。 辐射检测器被配置为检测在正电子发射断层摄影（PET）检查区域中由正电子 - 电子湮灭事件产生的γ射线。 辐射检测器包括电子加速器元件，其具有基本上平行于或与静磁场平行的电子加速度方向。 在一些实施例中，磁体是具有设置在磁共振检查区域的相对侧上的第一和第二间隔开的磁极片的开放磁体，并且辐射检测器包括第一和第二辐射检测器阵列，其布置有第一和第二间隔开 磁极片。

公开(公告)号：US08519710B2

公开(公告)日：2013-08-27

申请号：US13456470

申请日：2012-04-26

申请人： Volkmar Schulz ,  Torsten Solf ,  Johan Overweg ,  Andreas Thon

发明人： Volkmar Schulz ,  Torsten Solf ,  Johan Overweg ,  Andreas Thon

IPC分类号： G01V3/00

CPC分类号： A61B5/0035 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  G01R33/481 ,  G01T1/1603

摘要： In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

摘要翻译： 在组合系统中，磁共振（MR）扫描器包括配置成至少在从其获取MR数据的MR检查区域中产生静态磁场的磁体。 辐射检测器被配置为检测在正电子发射断层摄影（PET）检查区域中由正电子 - 电子湮灭事件产生的γ射线。 辐射检测器包括电子加速器元件，其具有基本上平行于或与静磁场平行的电子加速度方向。 在一些实施例中，磁体是具有设置在磁共振检查区域的相对侧上的第一和第二间隔开的磁极片的开放磁体，并且辐射检测器包括第一和第二辐射检测器阵列，其布置有第一和第二间隔开的 磁极片。

公开(公告)号：US20120206139A1

公开(公告)日：2012-08-16

申请号：US13456470

申请日：2012-04-26

申请人： Volkmar SCHULZ ,  Torsten SOLF ,  Johan OVERWEG ,  Andreas THON

发明人： Volkmar SCHULZ ,  Torsten SOLF ,  Johan OVERWEG ,  Andreas THON

IPC分类号： G01R33/44 ,  G01T1/164

CPC分类号： A61B5/0035 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  G01R33/481 ,  G01T1/1603

摘要： In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

摘要翻译： 在组合系统中，磁共振（MR）扫描器包括配置成至少在从其获取MR数据的MR检查区域中产生静态磁场的磁体。 辐射检测器被配置为检测在正电子发射断层摄影（PET）检查区域中由正电子 - 电子湮灭事件产生的γ射线。 辐射检测器包括电子加速器元件，其具有基本上平行于或与静磁场平行的电子加速度方向。 在一些实施例中，磁体是具有设置在磁共振检查区域的相对侧上的第一和第二间隔开的磁极片的开放磁体，并且辐射检测器包括第一和第二辐射检测器阵列，其布置有第一和第二间隔开的 磁极片。