公开(公告)号：US07884223B2

公开(公告)日：2011-02-08

申请号：US11667381

申请日：2005-11-10

申请人： Johannes Gerardus (Hans) De Vries ,  Gerardus Karel Maria Verzijl ,  Andreas Hendrikus Maria De Vries ,  Vincent Ritleng ,  Adeline Marie Joseèphe Voelklin

发明人： Johannes Gerardus (Hans) De Vries ,  Gerardus Karel Maria Verzijl ,  Andreas Hendrikus Maria De Vries ,  Vincent Ritleng ,  Adeline Marie Joseèphe Voelklin

IPC分类号： C07F15/00 ,  B01J31/00

CPC分类号： C07F17/02

摘要： The invention relates to an enantiomerically enriched chiral compound comprising a transition metal M, which comprises four, five or six coordinating groups of which at least one pair is linked together to form a bidentate ligand, in which M is directly bound via one single σ-bond to a carbon atom of an optionally substituted and/or optionally fused (hetero)aromatic ring of said bidentate ligand and in which M is directly bound to a nitrogen atom of a primary or secondary amino group of said bidentate ligand, thereby forming a metallacycle between said bidentate ligand and the metal M, said metal M being selected from the metals of groups 8 and 9 of the Periodic Table of the Elements, in particular iron, ruthenium, osmium, cobalt, rhodium, or iridium. The chiral compound can be used as a catalyst, preferably in an asymmetric transfer hydrogenation process. The invention further relates to a process for an asymmetric transfer hydrogenation of a prochiral compound in the presence of a hydrogen donor and the chiral compound of the invention comprising a transition metal chosen from the metals of groups 8, 9 and 10 of the Periodic Table, in particular iron, ruthenium, osmium, cobalt, rhodium, iridium, nickel, palladium or platinum as the catalyst.

摘要翻译： 本发明涉及包含过渡金属M的对映异构体富集的手性化合物，其包含四个，五个或六个配位基团，其中至少一对连接在一起形成双齿配体，其中M通过一个单一的直接结合; 与所述二齿配位体的任选取代的和/或任选稠合的（杂）芳族环的碳原子键合，并且其中M直接键合到所述二齿配位体的伯或仲氨基的氮原子上，从而形成 所述二齿配体和金属M之间的金属循环，所述金属M选自元素周期表第8和9族的金属，特别是铁，钌，锇，钴，铑或铱。 手性化合物可以用作催化剂，优选在不对称转移氢化方法中。 本发明还涉及在氢供体和含有选自元素周期表第8,9和10族的金属的过渡金属的本发明的手性化合物的存在下前手性化合物的不对称转移氢化的方法， 特别是铁，钌，锇，钴，铑，铱，镍，钯或铂作为催化剂。