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公开(公告)号：US08329699B2
公开(公告)日：2012-12-11
申请号：US13110053
申请日：2011-05-18
申请人： Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen Lynch , Timothy D. Owens , Michael Soth , Calvin Yee
发明人： Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen Lynch , Timothy D. Owens , Michael Soth , Calvin Yee
IPC分类号： A61K31/495
CPC分类号： C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R1 and R2 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量Q和R 1和R 2如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号：US20110288097A1
公开(公告)日：2011-11-24
申请号：US13110053
申请日：2011-05-18
申请人： Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen Lynch , Timothy D. Owens , Michael Soth , Calvin Yee
发明人： Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen Lynch , Timothy D. Owens , Michael Soth , Calvin Yee
IPC分类号： A61K31/4985 , A61P37/02 , A61P3/10 , A61P17/02 , A61P17/06 , A61P25/28 , A61P35/02 , A61P11/06 , A61P35/00 , C07D471/04 , A61P1/00
CPC分类号： C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R1 and R2 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量Q和R 1和R 2如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号：US20110230414A1
公开(公告)日：2011-09-22
申请号：US13039433
申请日：2011-03-03
申请人： Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen M. Lynch , Timothy D. Owens , Michael Soth
发明人： Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen M. Lynch , Timothy D. Owens , Michael Soth
IPC分类号： A61K38/00 , C07D487/04 , A61K31/4985 , A61P29/00 , A61P35/00 , A61P9/00 , A61P3/10 , A61P19/02 , A61P37/06 , A61P11/06 , A61P1/04 , A61P5/02 , A61P25/28
CPC分类号： C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q, R2, R3, and Y are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量Q，R2，R3和Y如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病 。
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公开(公告)号：US20110288067A1
公开(公告)日：2011-11-24
申请号：US13110062
申请日：2011-05-18
申请人： Robert Than Hendricks , Johannes Hermann , Saul Jaime-Figueroa , Rama Kondru , Yan Lou , Stephen Lynch , Timothy D. Owens , Michael Soth , Calvin Yee
发明人： Robert Than Hendricks , Johannes Hermann , Saul Jaime-Figueroa , Rama Kondru , Yan Lou , Stephen Lynch , Timothy D. Owens , Michael Soth , Calvin Yee
IPC分类号： A61K31/4985 , C07D295/155 , C07D491/107 , A61K31/541 , A61P29/00 , A61P37/00 , A61P35/00 , A61P25/00 , A61P9/00 , A61P3/10 , A61P37/04 , A61P11/06 , A61P19/04 , A61P17/06 , A61P37/06 , A61P17/00 , A61P5/14 , A61P1/04 , A61P1/00 , A61P25/28 , A61P35/02 , C07D487/04
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R, R2, and R3 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量Q和R，R2和R3如本文所述定义，其抑制JAK和SYK，并且可用于治疗自身免疫和炎性疾病 。
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公开(公告)号：US08518945B2
公开(公告)日：2013-08-27
申请号：US13040310
申请日：2011-03-04
申请人： Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen M. Lynch , Timothy D. Owens , Michael Soth
发明人： Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen M. Lynch , Timothy D. Owens , Michael Soth
IPC分类号： A61K31/495
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables n, p, q, Q, X, X′ and Y are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量n，p，q，Q，X，X'和Y如本文所述定义，其抑制JAK和SYK，并且可用于治疗 自身免疫和炎性疾病。
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公开(公告)号：US20110230462A1
公开(公告)日：2011-09-22
申请号：US13040310
申请日：2011-03-04
申请人： Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen M. Lynch , Timothy D. Owens , Michael Soth
发明人： Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen M. Lynch , Timothy D. Owens , Michael Soth
IPC分类号： A61K31/4985 , C07D487/04 , A61P29/00 , A61P35/00 , A61P37/00 , A61P9/00 , A61P3/10 , A61P11/06 , A61P17/06 , A61P25/28 , A61K31/5377 , A61K31/541
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables n, p, q, Q, X, X′ and Y are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量n，p，q，Q，X，X'和Y如本文所述定义，其抑制JAK和SYK，并且可用于治疗 自身免疫和炎性疾病。
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公开(公告)号：US08481541B2
公开(公告)日：2013-07-09
申请号：US13039433
申请日：2011-03-03
申请人： Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen M. Lynch , Timothy D. Owens , Michael Soth
发明人： Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen M. Lynch , Timothy D. Owens , Michael Soth
IPC分类号： A61K31/495
CPC分类号： C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q, R2, R3, and Y are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量Q，R2，R3和Y如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病 。
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