公开(公告)号：US5637087A

公开(公告)日：1997-06-10

申请号：US408767

申请日：1995-03-22

申请人： John A. O'Neil ,  John M. Hofstetter

发明人： John A. O'Neil ,  John M. Hofstetter

IPC分类号： A61M5/28 ,  A61M37/00

CPC分类号： A61M5/284 ,  A61M5/282 ,  A61M5/288

摘要： A prefilled, two-constituent system is provided with a syringe barrel having a dispensing end with an inwardly directed, stationary, piercing cannula. Within the syringe barrel is a first, sealed, collapsible container holding a first constituent at subatmospheric pressure. The first container is slidably disposed within the syringe barrel adjacent the piercing cannula. A second, sealed, collapsible container holding a liquid second constituent is slidably disposed within the syringe barrel spaced from the first container. A carrier is slidably disposed within the syringe barrel between the first and second containers. The carrier has a double-ended, hollow, piercing needle with oppositely extending first and second ends for piercing the first and second containers, respectively. A plunger is slidably mounted within the syringe barrel for applying a force to the second container.

摘要翻译： 具有注射器筒的预充填的双组分系统具有分配端，所述分配端具有向内定向的穿刺插管。 在注射器筒内是第一个密封的，可压缩的容器，其在低于大气压的压力下容纳第一组分。 第一容器可滑动地设置在与穿刺套管相邻的注射器筒内。 容纳液体第二成分的第二密封的可折叠容器可滑动地设置在与第一容器间隔开的注射器筒内。 载体可滑动地设置在第一和第二容器之间的注射器筒内。 载体具有双端，中空的刺穿针，其具有相对延伸的第一和第二端，用于分别刺穿第一和第二容器。 柱塞可滑动地安装在注射器筒内，用于向第二容器施加力。

公开(公告)号：US5569193A

公开(公告)日：1996-10-29

申请号：US408463

申请日：1995-03-22

申请人： John M. Hofstetter ,  John A. O'Neil ,  Richard W. Grabenkort

发明人： John M. Hofstetter ,  John A. O'Neil ,  Richard W. Grabenkort

IPC分类号： A61M5/31 ,  A61M5/315 ,  A61M37/00

CPC分类号： A61M5/31596 ,  A61M2005/3121 ,  A61M2005/3128 ,  A61M2005/31598

摘要： A prefilled, two-constituent system is provided with first and second containers. The first container includes a first chamber having a dispensing end. The dispensing end defines a dispensing passage communicating through the dispensing end to accommodate the dispensing of fluid from the first chamber. A movable seal is slidably disposed in the first chamber, and a first constituent is provided in the first chamber between the dispensing end and the seal. A second container includes a barrel that is sized to be disposed in the first container and that has a discharge end defining a discharge passage communicating through the discharge end to accommodate the discharge of fluid from the barrel. A plunger is slidably disposed within the barrel. A liquid second constituent is provided in the barrel between the discharge end and the plunger. The first container seal and the second container barrel discharge ends are engageable to cooperatively define a coupling accommodating the flow of the liquid second constituent from the second container barrel into the first chamber of the first container as the barrel moves outwardly relative to the first chamber.

摘要翻译： 预填充的双组分系统设置有第一和第二容器。 第一容器包括具有分配端的第一室。 分配端限定通过分配端连通的分配通道，以适应来自第一室的流体分配。 可移动密封件可滑动地设置在第一腔室中，第一构件在分配端和密封件之间的第一腔室中设置。 第二容器包括容积尺寸设置在第一容器中并且具有限定通过排出端连通的排出通道以适应流体从筒体排出的排出通道的筒体。 柱塞可滑动地设置在筒内。 液体第二组分设置在排出端和柱塞之间的筒体中。 第一容器密封件和第二容器筒排出端部可接合以协作地限定一个联接器，当机筒相对于第一腔室向外移动时，联接器容纳液体第二构件从第二容器筒体流入第一容器的第一腔室。

公开(公告)号：US5876372A

公开(公告)日：1999-03-02

申请号：US916903

申请日：1997-08-21

申请人： Richard W. Grabenkort ,  John M. Hofstetter ,  John A. O'Neil

发明人： Richard W. Grabenkort ,  John M. Hofstetter ,  John A. O'Neil

IPC分类号： A61M5/31 ,  A61M5/315 ,  A61M37/00

CPC分类号： A61M5/31596 ,  A61M2005/3121 ,  A61M2005/3128 ,  A61M2005/31598

摘要： A prefilled, two-constituent system is provided with first and second containers or barrels. The first barrel includes a first chamber having a dispensing end or delivery end. The delivery end defines a dispensing passage or delivery passage communicating through the delivery end to accommodate the dispensing of fluid from the first chamber. A movable seal or reciprocable stopper is slidably disposed in the first chamber, and a first constituent is provided in the first chamber between the delivery end and the stopper. A second container or barrel is sized to be disposed in the first barrel and has a discharge end defining a discharge passage communicating through the discharge end to accommodate the discharge of fluid from the second barrel. A plunger is slidably disposed within the second barrel. A liquid second constituent is provided in the second barrel between the discharge end and the plunger. The first barrel stopper and the second barrel discharge end are engageable directly or indirectly to cooperatively define a coupling accommodating the flow of the liquid second constituent from the second barrel into the first chamber of the first barrel as the second barrel moves outwardly relative to the first chamber.

摘要翻译： 预填充的双组分系统设置有第一和第二容器或桶。 第一桶包括具有分配端或输送端的第一室。 输送端限定分配通道或输送通道，其通过输送端连通以适应来自第一室的流体的分配。 可移动的密封件或可往复运动的塞子可滑动地设置在第一腔室中，并且第一构件在第一腔室中设置在输送端和塞子之间。 第二容器或筒的尺寸设置成设置在第一筒中，并且具有限定通过排出端连通的排放通道的排放端，以适应来自第二筒的流体的排放。 柱塞可滑动地设置在第二筒内。 在排出端和柱塞之间的第二筒体中设置液体第二成分。 第一筒塞和第二筒排放端可直接或间接地接合，以协作地限定一个联接器，当第二筒相对于第一筒排出端向外移动时，该联接器将液体第二成分从第二筒体的流动容纳到第一桶的第一室中 房间。