公开(公告)号：US20120270801A1

公开(公告)日：2012-10-25

申请号：US13505493

申请日：2010-10-27

申请人： Fredrik Frejd ,  Elin Gunneriusson ,  Nina Kronqvist ,  John Löfblom ,  Stefan Ståhl

发明人： Fredrik Frejd ,  Elin Gunneriusson ,  Nina Kronqvist ,  John Löfblom ,  Stefan Ståhl

IPC分类号： C07K14/31 ,  C12N15/63 ,  A61P35/00 ,  C07K19/00 ,  A61K38/16 ,  C12N15/31 ,  C12N1/21

CPC分类号： C07K16/32 ,  C07K14/31 ,  C07K14/705 ,  C07K16/2863 ,  C07K2318/20 ,  C07K2319/21 ,  C07K2319/31

摘要： The disclosure provides a HER3 binding polypeptide, comprising a HER3 binding motif, BM, which motif consists of the amino acid sequence selected from i) EX2X3X4A X6X7EIW X11LPNL X16X17X18QX20 X21AFIX25 X26LX28D, and ii) an N amino acid sequence which has at least 90% identity to the sequence defined in i), wherein the polypeptide binds to the extra-cellular domain of HER3. Also provided is a bispecific ligand having binding affinity for HER3 and for HER2, or for HER3 and for EGFR, and comprising a HER3. binding polypeptide as defined herein and a HER2 binding polypeptide or a EGFR binding polypeptide.

摘要翻译： 本公开提供了HER3结合多肽，其包含HER3结合基序BM，该基序由选自i）EX2X3X4A X6X7EIW X11LPNL X16X17X18QX20 X21AFIX25 X26LX28D的氨基酸序列组成，以及ii）具有至少90％同一性的N个氨基酸序列 至i）中定义的序列，其中所述多肽结合HER3的细胞外结构域。 还提供了对HER3和HER2或HER3和EGFR具有结合亲和力并包含HER3的双特异性配体。 和HER2结合多肽或EGFR结合多肽。

公开(公告)号：US10208128B2

公开(公告)日：2019-02-19

申请号：US13505493

申请日：2010-10-27

申请人： Fredrik Frejd ,  Elin Gunneriusson ,  Nina Kronqvist ,  John Löfblom ,  Stefan Ståhl

发明人： Fredrik Frejd ,  Elin Gunneriusson ,  Nina Kronqvist ,  John Löfblom ,  Stefan Ståhl

IPC分类号： C07K14/31 ,  C07K14/00 ,  C07K16/32 ,  C07K14/705 ,  C07K16/28

摘要： The disclosure provides a HER3 binding polypeptide, comprising a HER3 binding motif, BM, which motif consists of the amino acid sequence selected from i) EX2X3X4A X6X7EIW X11LPNL X16X17X18QX20 X21AFIX25 X26LX28D, and ii) an amino acid sequence which has at least 90% identity to the sequence defined in i), wherein the polypeptide binds to the extra-cellular domain of HER3. Also provided is a bispecific ligand having binding affinity for HER3 and for HER2, or for HER3 and for EGFR, and comprising a HER3. binding polypeptide as defined herein and a HER2 binding polypeptide or a EGFR binding polypeptide.