公开(公告)号：US06358060B2

公开(公告)日：2002-03-19

申请号：US09146696

申请日：1998-09-03

申请人： John M. Pinney ,  Jack E. Henningfield ,  Saul Shiffman ,  Joseph Gitchell ,  Edward J. Cone

发明人： John M. Pinney ,  Jack E. Henningfield ,  Saul Shiffman ,  Joseph Gitchell ,  Edward J. Cone

IPC分类号： A61F1302

CPC分类号： A61K31/4439 ,  A61K9/0058 ,  A61K9/1623 ,  Y10S514/813

摘要： A two-stage medicine delivery system provides an initial dose of medicine and a second dose of medicine. The initial second doses are capable of achieving a rapid pharmacological effect and a prolonged pharmacological effect, respectively. The two-stage medicine delivery system preferably delivers a craving reduction substance, in which case, the rapid and prolonged pharmacological effects include a rapid and prolonged craving reduction. Preferably, the delivery system is a nicotine delivery system which is provided in chewing gum form or lozenge form and which provides the nicotine in a transmucosally absorbable form. The two-stage medicine delivery system preferably releases a buffering agent which increases a pH level in a user's mouth to facilitate absorption of the medicine when the delivery system is placed in the user's mouth. A method of making the medicine delivery system also is provided. The system and apparatus can be adapted to reduce cravings for alcohol, food, drugs (e.g., cocaine, opiates and the like) and tobacco products, especially tobacco products containing nicotine.

摘要翻译： 两阶段药物递送系统提供初始剂量的药物和第二剂量的药物。 初始的第二剂量能分别达到快速的药理作用和延长的药理作用。 两级药物递送系统优选递送渴望还原物质，在这种情况下，快速和长期的药理作用包括快速和延长的渴望减少。 优选地，递送系统是以口香糖形式或锭剂形式提供的尼古丁递送系统，其以经粘膜吸收形式提供尼古丁。 两级药物递送系统优选释放缓冲剂，其在使用者的口中增加pH水平，以便当将递送系统放置在使用者的嘴中时便于吸收药物。 还提供了制备药物递送系统的方法。 该系统和装置可以适用于减少酒精，食品，药物（例如可卡因，阿片剂等）和烟草制品，特别是含有尼古丁的烟草制品的渴望。

公开(公告)号：US08642016B2

公开(公告)日：2014-02-04

申请号：US11878163

申请日：2007-07-20

申请人： Tommy L. Chau ,  John M. Pinney ,  Jack E. Henningfield ,  Edward J. Cone ,  Saul M. Shiffman ,  Joseph G. Gitchell

发明人： Tommy L. Chau ,  John M. Pinney ,  Jack E. Henningfield ,  Edward J. Cone ,  Saul M. Shiffman ,  Joseph G. Gitchell

IPC分类号： A61K9/68

CPC分类号： A61K9/0058 ,  A61K9/0056 ,  A61K31/4406 ,  A61K31/465

摘要： A method is provided of making a medicinal delivery system which satiates a craving in an individual when the medicinal delivery system is administered orally to the individual. A coating composition is applied on a saliva-soluble powder to establish a coated powder, the coating composition featuring an at least partially solubilized craving satiation medicinal compound. The coated powder is combined with an edible carrier base to establish a medicinal delivery system that rapidly releases medicine and buffer preferably followed by slower, sustained release.

摘要翻译： 提供了一种制备药物递送系统的方法，该药物递送系统当药物递送系统被口服给予个人时，使个体的渴望变得饱满。 将涂料组合物施加到唾液可溶性粉末上以建立涂覆粉末，所述涂料组合物的特征在于至少部分溶解的渴望饱和药物化合物。 将涂覆的粉末与可食用载体基质结合以建立药物递送系统，其快速释放药物并缓冲，优选缓慢，持续释放。

公开(公告)号：US06344222B1

公开(公告)日：2002-02-05

申请号：US09389339

申请日：1999-09-02

申请人： Subraman R. Cherukuri ,  John M. Pinney ,  Jack E. Henningfield ,  Aradhana Sasan ,  Edward J. Cone ,  Saul Shiffman ,  Joe Gitchell ,  Carlos D. Malvestutto

发明人： Subraman R. Cherukuri ,  John M. Pinney ,  Jack E. Henningfield ,  Aradhana Sasan ,  Edward J. Cone ,  Saul Shiffman ,  Joe Gitchell ,  Carlos D. Malvestutto

IPC分类号： A23G330

CPC分类号： A61K9/0058 ,  A61K9/1623

摘要： A chewing gum delivery system has nicotine, gum base and a buffer system with an improved release rate for the nicotine. The resulting delivery system advantageously provides a convenient, reliable, practical, and relatively painless system for delivering an active. The delivery system is capable of delivering initial and second doses of a craving reduction active or other actives (e.g., nicotine), the combination of which rapidly reduces cravings, or provides some other pharmacological effect, and provides the pharmacological effect or protection from such cravings over a prolonged period of time beyond the initial dose. Notably, the delivery system is capable of rapidly achieving a pharmacologically effective concentration of the active (e.g., nicotine) in the bloodstream (e.g., within 5 minutes, or more desirably within 3 minutes, or in some cases, within 1-2 minutes), and is also capable of keeping the concentration of the active in the bloodstream at or near the pharmacologically effective concentration for at least 20 minutes after chewing of the delivery system begins, or more desirably about 30 minutes to about 50 minutes after chewing begins.

摘要翻译： 口香糖输送系统具有尼古丁，胶基和缓冲系统，其尼古丁具有改善的释放速率。 所得到的递送系统有利地提供了用于递送活性物质的方便，可靠，实用和相对无痛的系统。 递送系统能够提供初始和第二剂量的减渴活性物质或其它活性物质（例如尼古丁），其组合可以快速减少渴望，或提供一些其他药理作用，并提供药理作用或防止这种渴求 超过初始剂量的长时间。 值得注意的是，递送系统能够迅速地实现血流中活性物质（例如，尼古丁）的药理学有效浓度（例如，在5分钟内，或更理想地在3分钟内，或在一些情况下，在1-2分钟内） 并且还能够在开始咀嚼输送系统之后保持血液中活性物质浓度达到或接近药理学有效浓度至少20分钟，或更理想地在咀嚼开始后约30分钟至约50分钟。

公开(公告)号：US20080187589A1

公开(公告)日：2008-08-07

申请号：US12026303

申请日：2008-02-05

申请人： JOHN M. PINNEY ,  Edward J. Cone ,  Tommy L. Chau ,  August R. Buchhalter

发明人： JOHN M. PINNEY ,  Edward J. Cone ,  Tommy L. Chau ,  August R. Buchhalter

IPC分类号： A61K9/24 ,  A61K9/20 ,  A61P37/08 ,  A61K31/4545

CPC分类号： A61K9/0056 ,  A61K31/135 ,  A61K31/4545

摘要： A multi-modal absorption, medicine-delivery lozenge is provided. The lozenge includes a lozenge base for oral administration into a user's mouth, a medicinal active ingredient including an antihistamine convertible between ionized and non-ionized states, and a buffer present in an effective amount for establishing a pH in the individual's mouth which is characterized by a simultaneous presence of a first pharmacologically effective dose of the non-ionized form of the medicinal active ingredient for transmucosal absorption, and a second pharmacologically effective dose of the ionized form of the medicinal active ingredient for gastro-intestinal absorption.

摘要翻译： 提供了一种多模式吸收药物递送锭剂。 锭剂包括用于口服给药于使用者口中的锭剂基料，包括可在电离和非离子化状态之间转化的抗组胺剂的药物活性成分和以个体口中建立pH的有效量的缓冲剂，其特征在于： 同时存在用于经粘膜吸收的第一药理有效剂量的非电离形式的药用活性成分，以及用于胃肠吸收的第二药理学有效剂量的电离形式的药用活性成分。

公开(公告)号：US06893654B2

公开(公告)日：2005-05-17

申请号：US10098307

申请日：2002-03-18

申请人： John M. Pinney ,  Jack E. Henningfield ,  Saul Shiffman ,  Joseph Gitchell ,  Edward J. Cone

发明人： John M. Pinney ,  Jack E. Henningfield ,  Saul Shiffman ,  Joseph Gitchell ,  Edward J. Cone

IPC分类号： A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K9/68 ,  A61K31/4439 ,  A61F13/00 ,  A61K9/14 ,  A61K9/48

CPC分类号： A61K31/4439 ,  A61K9/0058 ,  A61K9/1623 ,  Y10S514/813

摘要： A two-stage medicine delivery system provides an initial dose of medicine and a second dose of medicine. The initial and second doses are capable of achieving a rapid pharmacological effect and a prolonged pharmacological effect, respectively. The two-stage medicine delivery system preferably delivers a craving reduction substance, in which case, the rapid and prolonged pharmacological effects include a rapid and prolonged craving reduction. Preferably, the delivery system is a nicotine delivery system which is provided in chewing gum form or lozenge form and which provides the nicotine in a transmucosally absorbable form. The two-stage medicine delivery system preferably releases a buffering agent which increases a pH level in a user's mouth to facilitate absorption of the medicine when the delivery system is placed in the user's mouth. A method of making the medicine delivery system also is provided. The system and apparatus can be adapted to reduce cravings for alcohol, food, drugs (e.g., cocaine, opiates and the like) and tobacco products, especially tobacco products containing nicotine.

摘要翻译： 两阶段药物递送系统提供初始剂量的药物和第二剂量的药物。 初始剂量和第二剂量能分别达到快速的药理作用和延长的药理作用。 两级药物递送系统优选递送渴望还原物质，在这种情况下，快速和长期的药理作用包括快速和延长的渴望减少。 优选地，递送系统是以口香糖形式或锭剂形式提供的尼古丁递送系统，其以经粘膜吸收形式提供尼古丁。 两级药物递送系统优选释放缓冲剂，其在使用者的口中增加pH水平，以便当将递送系统放置在使用者的嘴中时便于吸收药物。 还提供了制备药物递送系统的方法。 该系统和装置可以适用于减少酒精，食品，药物（例如可卡因，阿片剂等）和烟草制品，特别是含有尼古丁的烟草制品的渴望。