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公开(公告)号：US08435490B2
公开(公告)日：2013-05-07
申请号：US12664302
申请日：2008-06-04
摘要： Cancers are extremely heterogeneous in terms of the frequency and types of mutations present in different malignant tumors. Thus, it is likely that uniform clinical treatment is not optimal for all patients, and that the development of individualized therapeutic regimens may be beneficial. Multiple, unique small peptides bind to cell lines derived from different colon adenocarcinomas. Within two hours of contact, the colorectal cancer cells are able to transfer a 32P radioisotope from the small peptides to cellular proteins; the transfer occurs at a substantially higher rate than in the colorectal cancer cells than in cell lines derived from other cancers or from normal tissues.
摘要翻译： 在不同恶性肿瘤中存在的突变的频率和类型方面，癌症是非常不均匀的。 因此，对于所有患者来说，统一的临床治疗可能不是最佳的，个体化治疗方案的发展可能是有益的。 多个独特的小肽结合来自不同结肠腺癌的细胞系。 在接触两小时后，结肠直肠癌细胞能够将32P放射性同位素从小肽转移到细胞蛋白质; 转移发生在比结肠直肠癌细胞中显着更高的速率，而不是来源于其他癌症或来自正常组织的细胞系。
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公开(公告)号：US20100183511A1
公开(公告)日：2010-07-22
申请号：US12664302
申请日：2008-06-04
摘要： Cancers are extremely heterogeneous in terms of the frequency and types of mutations present in different malignant tumors. Thus, it is likely that uniform clinical treatment is not optimal for all patients, and that the development of individualized therapeutic regimens may be beneficial. Multiple, unique small peptides bind to cell lines derived from different colon adenocarcinomas. Within two hours of contact, the colorectal cancer cells are able to transfer a 32P radioisotope from the small peptides to cellular proteins; the transfer occurs at a substantially higher rate than in the colorectal cancer cells than in cell lines derived from other cancers or from normal tissues.
摘要翻译： 在不同恶性肿瘤中存在的突变的频率和类型方面，癌症是非常不均匀的。 因此，对于所有患者来说，统一的临床治疗可能不是最佳的，个体化治疗方案的发展可能是有益的。 多个独特的小肽结合来自不同结肠腺癌的细胞系。 在接触两小时后，结肠直肠癌细胞能够将32P放射性同位素从小肽转移到细胞蛋白质; 转移发生在比结肠直肠癌细胞中显着更高的速率，而不是来源于其他癌症或来自正常组织的细胞系。
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