公开(公告)号：US10780140B2

公开(公告)日：2020-09-22

申请号：US15832053

申请日：2017-12-05

申请人： John P. Crow, Jr.

发明人： John P. Crow, Jr.

IPC分类号： A61K36/61 ,  C07D307/32 ,  C07D307/30

摘要： The present invention relates to methods and strategies for extracting nitrosylated and/or nitrated derivatives and analogs from Myrciaria dubia fruit and for synthesizing the same. The ascorbic acid derivatives and analogs have the chemical structure of: where R1 is ═O, —ONO, —ONO2, or —NH2; R2 is —OH, —ONO, —ONO2, or —NH2; R3 is —OH, —ONO, —ONO2. The extraction method comprises freeze-drying the Myrciaria dubia fruit, mixing the freeze-dried powder with a solvent and separating and drying the supernatant. The synthetic method comprises derivatizing an ascorbic acid via nitrosylation and/or nitration in a buffered ascorbic acid solution, reducing zero or more nitro groups to an amine group, and purifying the ascorbic acid analog.

公开(公告)号：US20180092957A1

公开(公告)日：2018-04-05

申请号：US15832053

申请日：2017-12-05

申请人： John P. Crow, JR.

发明人： John P. Crow, JR.

IPC分类号： A61K36/61 ,  C07D307/30 ,  C07D307/32

CPC分类号： A61K36/61 ,  A61K2236/17 ,  A61K2236/33 ,  A61K2236/331 ,  A61K2236/53 ,  C07D307/30 ,  C07D307/32

摘要： The present invention relates to methods and strategies for extracting nitrosylated and/or nitrated derivatives and analogs from Myriciaria dubia fruit and for synthesizing the same. The ascorbic acid derivatives and analogs have the chemical structure of: where R1 is ═O, —ONO, —ONO2, or —NH2; R2 is —OH, —ONO, —ONO2, or —NH2; R3 is —OH, —ONO, —ONO2. The extraction method comprises freeze-drying the Myriciaria dubia fruit, mixing the freeze-dried powder with a solvent and separating and drying the supernatant. The synthetic method comprises derivatizing an ascorbic acid via nitrosylation and/or nitration in a buffered ascorbic acid solution, reducing zero or more nitro groups to an amine group, and purifying the ascorbic acid analog.

公开(公告)号：US20160361373A1

公开(公告)日：2016-12-15

申请号：US15177987

申请日：2016-06-09

申请人： John P. Crow, JR.

发明人： John P. Crow, JR.

IPC分类号： A61K36/61 ,  C07D307/30 ,  C07D307/32

CPC分类号： A61K36/61 ,  A61K2236/17 ,  A61K2236/33 ,  A61K2236/331 ,  A61K2236/53 ,  C07D307/30 ,  C07D307/32

摘要： The present invention relates to methods and strategies for extracting nitrosylated and/or nitrated derivatives and analogs from Myriciaria dubia fruit and for synthesizing the same. The ascorbic acid derivatives and analogs have the chemical structure of: where R1 is ═O, —ONO, —ONO2, or —NH2; R2 is —OH, —ONO, —ONO2, or —NH2; R3 is —OH, —ONO, —ONO2. The extraction method comprises freeze-drying the Myriciaria dubia fruit, mixing the freeze-dried powder with a solvent and separating and drying the supernatant. The synthetic method comprises derivatizing an ascorbic acid via nitrosylation and/or nitration in a buffered ascorbic acid solution, reducing zero or more nitro groups to an amine group, and purifying the ascorbic acid analog.

摘要翻译： 其中R 1为= O，-ONO，-ONO 2或-NH 2; R2是-OH，-ONO，-ONO2或-NH2; R3是-OH，-ONO，-ONO2。 提取方法包括将Myriciaria dubia果实冷冻干燥，将冷冻干燥的粉末与溶剂混合并分离和干燥上清液。 合成方法包括通过在缓冲的抗坏血酸溶液中的亚硝基化和/或硝化衍生抗坏血酸，将零个或多个硝基还原成胺基，并纯化抗坏血酸类似物。

公开(公告)号：US10105407B2

公开(公告)日：2018-10-23

申请号：US15177987

申请日：2016-06-09

申请人： John P. Crow, Jr.

发明人： John P. Crow, Jr.

IPC分类号： A61K36/61 ,  C07D307/32 ,  C07D307/30

摘要： The present invention relates to methods and strategies for extracting nitrosylated and/or nitrated derivatives and analogs from Myriciaria dubia fruit and for synthesizing the same. The ascorbic acid derivatives and analogs have the chemical structure of: where R1 is ═O, —ONO, —ONO2, or —NH2; R2 is —OH, —ONO, —ONO2, or —NH2; R3 is —OH, —ONO, —ONO2. The extraction method comprises freeze-drying the Myriciaria dubia fruit, mixing the freeze-dried powder with a solvent and separating and drying the supernatant. The synthetic method comprises derivatizing an ascorbic acid via nitrosylation and/or nitration in a buffered ascorbic acid solution, reducing zero or more nitro groups to an amine group, and purifying the ascorbic acid analog.