公开(公告)号：US20070224287A1

公开(公告)日：2007-09-27

申请号：US10573354

申请日：2004-09-27

申请人： Richard Wright ,  John Repine

发明人： Richard Wright ,  John Repine

IPC分类号： A61K31/519 ,  A61K33/24 ,  C12N9/02

CPC分类号： A61K31/519 ,  A61K31/00 ,  A61K33/24

摘要： Evidence is presented that inflammation and injury involves activation of xanthine oxidoreductase (XOR) in the newly recruited mononuclear phagocytes (MNP). XOR has been shown to be increased predominantly in the MNP that increase rapidly in the lungs of rats that develop acute lung injury (ALI) following intratracheal cytokine insufflation. XOR was recovered from the MNP largely converted to its oxygen radical generating, reversible O-form, and alveolar MNP exhibited increased oxidative stress as evidenced by increased nitrotyrosine staining. Cytokine insufflation also increased alveolar cell apoptosis. A functional role for XOR in cytokine induced inflammation was demonstrated. Tungsten and allopurinol decreased MNP XOR induction, nitrotyrosine staining, inflammatory cell infiltration, and alveolar cell apoptosis. Transfer of control or allopurinol treated MNP into rat lungs and confirmed a specific role for MNP XOR in promoting lung inflammation. These data indicate that XOR can contribute to lung inflammation by its expression and conversion in a highly mobile inflammatory cell population.

摘要翻译： 证据表明炎症和损伤涉及新招募的单核吞噬细胞（MNP）中黄嘌呤氧化还原酶（XOR）的活化。 已显示XOR主要在MNP中增加，其在气管内细胞因子吹入后发展为急性肺损伤（ALI）的大鼠肺中迅速增加。 通过增加的硝基酪氨酸染色证明，从MNP中回收的XOR大部分转化为其产生氧自由基的可逆O型，并且肺泡MNP显示增加的氧化应激。 细胞因子注入也增加肺泡细胞凋亡。 证明了XOR在细胞因子诱导炎症中的功能作用。 钨和别嘌醇降低MNP XOR诱导，硝基酪氨酸染色，炎症细胞浸润和肺泡细胞凋亡。 将对照或别嘌呤醇治疗的MNP转移到大鼠肺中，并确认MNP XOR在促进肺部炎症中的特异性作用。 这些数据表明XOR可以通过其在高度流动的炎性细胞群体中的表达和转化来促进肺部炎症。

公开(公告)号：US20050256384A1

公开(公告)日：2005-11-17

申请号：US10844230

申请日：2004-05-11

申请人： Stephen Walker ,  Peter Nelson ,  R. Zellers ,  Charles Henry ,  John Repine

发明人： Stephen Walker ,  Peter Nelson ,  R. Zellers ,  Charles Henry ,  John Repine

IPC分类号： A01N43/38 ,  A61B5/00 ,  A61K31/405

CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61K31/405

摘要： Glucose concentration is noninvasively measured by measuring a plurality of absorption values using at least one emitter operating at a corresponding plurality of emission wavelengths through a common optical sample volume and deriving glucose concentration from the absorption measurement values.

摘要翻译： 通过使用至少一个以相应的多个发射波长通过共同的光学样本体积操作的发射体测量多个吸收值，并从吸收测量值导出葡萄糖浓度来非葡萄糖浓度。