公开(公告)号：US20130012477A1

公开(公告)日：2013-01-10

申请号：US13469870

申请日：2012-05-11

申请人： John Thor Arnason ,  Tony Durst ,  Brian Foster

发明人： John Thor Arnason ,  Tony Durst ,  Brian Foster

IPC分类号： C07D317/64 ,  A01P7/04 ,  C07D317/54 ,  A01N65/12 ,  A61K31/36 ,  A01N43/30

CPC分类号： A01N43/30 ,  C07D317/54 ,  C07D317/64 ,  C07D317/68 ,  A01N2300/00 ,  A01N53/00

摘要： Derivatives of dillapiol, sesamol and related monolignans having the following general formula: These compounds have synergistic properties, inhibit cytochrome P450 enzymes such as human CYP3A4, and can be used as pesticide synergists or pharmaco-enhancers. Accordingly, methods for increasing the efficacy and/or bioavailability of a pharmaceutically active agent and for increasing the potency of a pesticide are described, as are synergistic pesticidal and pharmaceutical compositions.

摘要翻译： 狄拉波酚，芝麻酚和相关单宁酸衍生物具有以下通式：这些化合物具有协同作用，抑制细胞色素P450酶如人CYP3A4，可用作农药增效剂或药物增强剂。 因此，描述了用于提高药物活性剂的功效和/或生物利用度并提高农药效力的方法，协同杀虫剂和药物组合物也是如此。

公开(公告)号：US09386767B2

公开(公告)日：2016-07-12

申请号：US13469870

申请日：2012-05-11

申请人： John Thor Arnason ,  Tony Durst ,  Brian Foster

发明人： John Thor Arnason ,  Tony Durst ,  Brian Foster

IPC分类号： A01N43/30 ,  C07D317/54 ,  A01N53/00 ,  C07D317/64 ,  C07D317/68

CPC分类号： A01N43/30 ,  C07D317/54 ,  C07D317/64 ,  C07D317/68 ,  A01N2300/00 ,  A01N53/00

摘要： Derivatives of dillapiol, sesamol and related monolignans having the following general formula: These compounds have synergistic properties, inhibit cytochrome P450 enzymes such as human CYP3A4, and can be used as pesticide synergists or pharmaco-enhancers. Accordingly, methods for increasing the efficacy and/or bioavailability of a pharmaceutically active agent and for increasing the potency of a pesticide are described, as are synergistic pesticidal and pharmaceutical compositions.

摘要翻译： 狄拉波酚，芝麻酚和相关单宁酸衍生物具有以下通式：这些化合物具有协同作用，抑制细胞色素P450酶如人CYP3A4，可用作农药增效剂或药物增强剂。 因此，描述了用于提高药物活性剂的功效和/或生物利用度并提高农药效力的方法，协同杀虫剂和药物组合物也是如此。