公开(公告)号：US06599717B1

公开(公告)日：2003-07-29

申请号：US09677046

申请日：2000-09-29

申请人： Allen James Ebens, Jr. ,  R. Glenn Hammonds ,  Jonathan C. Heller ,  Greg Weddell ,  John W. Winslow

发明人： Allen James Ebens, Jr. ,  R. Glenn Hammonds ,  Jonathan C. Heller ,  Greg Weddell ,  John W. Winslow

IPC分类号： C07K1471

CPC分类号： C07K14/71

摘要： Vascular Endothelial Growth Factor Receptor (dmVEGFR) nucleic acids and proteins that have been isolated from Drosophila melanogaster are described. The dmVEGFR nucleic acids and proteins can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in dmVEGPR expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds which are potential therapeutics that interact with dmVEGFR protein. They can also be used in methods for studying dmVEGFR activity and identifying other genes that modulate the function of, or interact with, the dmVEGFR gene.

摘要翻译： 描述了已经从黑腹果蝇分离的血管内皮生长因子受体（dmVEGFR）核酸和蛋白质。 dmVEGFR核酸和蛋白质可用于遗传修饰后生动物无脊椎动物，如昆虫和蠕虫，或培养细胞，导致dmVEGPR表达或错误表达。 遗传修饰的生物体或细胞可用于筛选试验以鉴定与dmVEGFR蛋白相互作用的潜在治疗剂的候选化合物。 它们也可用于研究dmVEGFR活性的方法，并鉴定调节dmVEGFR基因功能或与之相互作用的其他基因。