公开(公告)号：US06217850B1

公开(公告)日：2001-04-17

申请号：US09084105

申请日：1998-05-26

申请人： Harald Dugstad ,  Jo Klaveness ,  Pål Rongved ,  Roald Skurtveit ,  Jorunn Braenden

发明人： Harald Dugstad ,  Jo Klaveness ,  Pål Rongved ,  Roald Skurtveit ,  Jorunn Braenden

IPC分类号： A61B800

CPC分类号： A61K49/223 ,  A61K49/227 ,  Y10T428/2982

摘要： Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful both as efficacious contrast agents per se and as intermediates in the preparation of contrast agents wherein the phospholipids are crosslinked or polymerised. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.

摘要翻译： 由主要包含单独具有整体净电荷的分子的磷脂稳定的微泡分散体表现出有利的稳定性，使得它们作为有效的造影剂本身以及作为制备造影剂的中间体是有用的，其中磷脂是交联或聚合的。 还公开了一种用于制备含微泡的造影剂的改进方法，其包括将由一种或多种形成膜的脂质稳定的气体微泡的水性分散体冻干以产生可在可注射载体液体中重构以产生微泡的干燥产物 含有造影剂。

公开(公告)号：US20050201942A1

公开(公告)日：2005-09-15

申请号：US11073027

申请日：2005-03-04

申请人： Harald Dugstad ,  Jo Klaveness ,  Pal Rongved ,  Roald Skurtveit ,  Jorunn Braenden

发明人： Harald Dugstad ,  Jo Klaveness ,  Pal Rongved ,  Roald Skurtveit ,  Jorunn Braenden

IPC分类号： A61K49/00 ,  A61K47/24 ,  A61K49/04 ,  A61K49/22

CPC分类号： A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  Y10T428/2982

摘要： Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful as efficacious contrast agents. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.

摘要翻译： 主要由包含单独具有整体净电荷的分子的磷脂稳定的微泡分散体显示出有利的稳定性，使其成为有效的造影剂。 还公开了一种用于制备含微泡的造影剂的改进方法，其包括将由一种或多种形成膜的脂质稳定的气体微泡的水性分散体冻干以产生可在可注射载体液体中重构以产生微泡的干燥产物 含有造影剂。