公开(公告)号：US08076297B2

公开(公告)日：2011-12-13

申请号：US11631880

申请日：2005-07-05

申请人： Maria del Carmen Abrahantes Pérez ,  Jesús Reyes González ,  Gloria Véliz Rios ,  Eduardo Martinez Diaz ,  Caridad Anais Gasmuri González ,  José Garcia Suárez ,  Mónica Bequet Romero ,  Luis Javier González López ,  Lila Rosa Castellanos Serra ,  Manuel Selman-Housein Sosa ,  Raúl Gómez Riera ,  Jorge Victor Gavilondo Cowley

发明人： Maria del Carmen Abrahantes Pérez ,  Jesús Reyes González ,  Gloria Véliz Rios ,  Eduardo Martinez Diaz ,  Caridad Anais Gasmuri González ,  José Garcia Suárez ,  Mónica Bequet Romero ,  Luis Javier González López ,  Lila Rosa Castellanos Serra ,  Manuel Selman-Housein Sosa ,  Raúl Gómez Riera ,  Jorge Victor Gavilondo Cowley

IPC分类号： A61K38/43 ,  C12N9/52

CPC分类号： A61K38/16

摘要： The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1-100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's “in vivo” administration has antitumoral, antiangiogenic and protective effect against malignant tumors.

摘要翻译： 本发明涉及能够抑制不同组织起源的肿瘤细胞和活化的内皮细胞的生长的组合物。 所述组合物的组分是对应于来自分子末端的内部甲硫氨酸的对应于C-末端片段的血清素的多肽片段，其可以在它们之间并且任选地与促进组合物的抗肿瘤作用的催乳素蛋白质组合 。 组合物中的生殖细胞可以是0.1-100nM的浓度。 该组合物的抗增殖作用由凋亡机制介导。 “体内”治疗对恶性肿瘤具有抗肿瘤，抗血管生成和保护作用。

公开(公告)号：US20110218138A1

公开(公告)日：2011-09-08

申请号：US11631880

申请日：2005-07-05

申请人： María Del Carmen Abrahantes Pérez ,  Jesús Reyes González ,  Gloria Véliz Rios ,  Eduardo Martínez Díaz ,  Caridad Anais Gasmuri González ,  José Garcia Suárez ,  Mónica Bequet Romero ,  Luis Javier González López ,  Lisa Rosa Castellanos Serra ,  Manuel Selman-Housein Sosa ,  Raúl Gómez Riera ,  Jorge Victor Gavilondo Cowley

发明人： María Del Carmen Abrahantes Pérez ,  Jesús Reyes González ,  Gloria Véliz Rios ,  Eduardo Martínez Díaz ,  Caridad Anais Gasmuri González ,  José Garcia Suárez ,  Mónica Bequet Romero ,  Luis Javier González López ,  Lisa Rosa Castellanos Serra ,  Manuel Selman-Housein Sosa ,  Raúl Gómez Riera ,  Jorge Victor Gavilondo Cowley

IPC分类号： A61K38/16 ,  C07K14/24 ,  A61P35/00 ,  A61P31/00 ,  A61P37/04 ,  A61P37/02

CPC分类号： A61K38/16

摘要： The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1-100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's “in vivo” administration has antitumoral, antiangiogenic and protective effect against malignant tumors.