Method of forming a polymerized hemoglobin solution from stabilized hemoglobin
    1.
    发明授权
    Method of forming a polymerized hemoglobin solution from stabilized hemoglobin 失效
    从稳定化血红蛋白形成聚合血红蛋白溶液的方法

    公开(公告)号:US07135554B1

    公开(公告)日:2006-11-14

    申请号:US10998861

    申请日:2004-11-29

    IPC分类号: C07K14/805

    CPC分类号: C08H1/02 C07K14/805

    摘要: A stabilized hemoglobin solution is contacted with polymerizing agent. The stabilized hemoglobin solution includes stabilized tetrameric hemoglobin. At least a portion of the stabilized tetrameric hemoglobin is polymerized by reaction with the polymerizing agent, thereby producing a polymerized hemoglobin solution. In one embodiment, the stabilized hemoglobin solution includes a filtrate formed by filtrating polymerized solution of native hemoglobin through a filter having a molecular weight cut off of about 100 kD.

    摘要翻译: 将稳定的血红蛋白溶液与聚合剂接触。 稳定的血红蛋白溶液包括稳定的四聚体血红蛋白。 至少一部分稳定的四聚体血红蛋白通过与聚合剂反应而聚合,由此产生聚合的血红蛋白溶液。 在一个实施方案中,稳定化的血红蛋白溶液包括通过将天然血红蛋白的聚合溶液通过截留约100kD的分子量的过滤器过滤而形成的滤液。

    METHOD OF FORMING A POLYMERIZED HEMOGLOBIN SOLUTION FROM STABILIZED HEMOGLOBIN
    2.
    发明申请
    METHOD OF FORMING A POLYMERIZED HEMOGLOBIN SOLUTION FROM STABILIZED HEMOGLOBIN 审中-公开
    从稳定的HEMOGLOBIN形成聚合的HEMOGLOBIN溶液的方法

    公开(公告)号:US20090137762A1

    公开(公告)日:2009-05-28

    申请号:US12326076

    申请日:2008-12-01

    IPC分类号: C08H1/02 C07K14/805

    CPC分类号: C08H1/02 C07K14/805

    摘要: A stabilized hemoglobin solution is contacted with polymerizing agent. The stabilized hemoglobin solution includes stabilized tetrameric hemoglobin. At least a portion of the stabilized tetrameric hemoglobin is polymerized by reaction with the polymerizing agent, thereby producing a polymerized hemoglobin solution. In one embodiment, the stabilized hemoglobin solution includes a filtrate formed by filtrating polymerized solution of native hemoglobin through a filter having a molecular weight cut off of about 100 kD.

    摘要翻译: 将稳定的血红蛋白溶液与聚合剂接触。 稳定的血红蛋白溶液包括稳定的四聚体血红蛋白。 至少一部分稳定的四聚体血红蛋白通过与聚合剂反应而聚合,由此产生聚合的血红蛋白溶液。 在一个实施方案中,稳定化的血红蛋白溶液包括通过将天然血红蛋白的聚合溶液通过截留约100kD的分子量的过滤器过滤而形成的滤液。

    Method of forming a polymerized hemoglobin solution from stabilized hemoglobin
    3.
    发明授权
    Method of forming a polymerized hemoglobin solution from stabilized hemoglobin 有权
    从稳定化血红蛋白形成聚合血红蛋白溶液的方法

    公开(公告)号:US07459535B2

    公开(公告)日:2008-12-02

    申请号:US11583363

    申请日:2006-10-19

    IPC分类号: C07K14/805

    CPC分类号: C08H1/02 C07K14/805

    摘要: A stabilized hemoglobin solution is contacted with polymerizing agent. The stabilized hemoglobin solution includes stabilized tetrameric hemoglobin. At least a portion of the stabilized tetrameric hemoglobin is polymerized by reaction with the polymerizing agent, thereby producing a polymerized hemoglobin solution. In one embodiment, the stabilized hemoglobin solution includes a filtrate formed by filtrating polymerized solution of native hemoglobin through a filter having a molecular weight cut off of about 100 kD.

    摘要翻译: 将稳定的血红蛋白溶液与聚合剂接触。 稳定的血红蛋白溶液包括稳定的四聚体血红蛋白。 至少一部分稳定的四聚体血红蛋白通过与聚合剂反应而聚合,由此产生聚合的血红蛋白溶液。 在一个实施方案中,稳定化的血红蛋白溶液包括通过将天然血红蛋白的聚合溶液通过截留约100kD的分子量的过滤器过滤而形成的滤液。