公开(公告)号：US5894340A

公开(公告)日：1999-04-13

申请号：US744678

申请日：1996-11-06

申请人： Thomas R. Loree, deceased ,  Irving J. Bigio ,  Joseph A. Zuclich ,  Tsutomu Shimada ,  Karlheinz Strobl

发明人： Thomas R. Loree, deceased ,  Irving J. Bigio ,  Joseph A. Zuclich ,  Tsutomu Shimada ,  Karlheinz Strobl

IPC分类号： A61B3/117 ,  A61B3/00

CPC分类号： A61B3/1176 ,  A61B3/10

摘要： Method for quantifying optical properties of the human lens. The present invention includes the application of fiberoptic, OMA-based instrumentation as an in vivo diagnostic tool for the human ocular lens. Rapid, noninvasive and comprehensive assessment of the optical characteristics of a lens using very modest levels of exciting light are described. Typically, the backscatter and fluorescence spectra (from about 300- to 900-nm) elicited by each of several exciting wavelengths (from about 300- to 600-nm) are collected within a few seconds. The resulting optical signature of individual lenses is then used to assess the overall optical quality of the lens by comparing the results with a database of similar measurements obtained from a reference set of normal human lenses having various ages. Several metrics have been identified which gauge the optical quality of a given lens relative to the norm for the subject's chronological age. These metrics may also serve to document accelerated optical aging and/or as early indicators of cataract or other disease processes.

摘要翻译： 用于量化人体晶状体的光学性质的方法。 本发明包括光纤，基于OMA的仪器作为人眼透镜的体内诊断工具的应用。 描述了使用非常适度水平的激发光的透镜的光学特性的快速，无创和全面的评估。 通常，在几秒钟内收集由几个激发波长（约300至600nm）中的每一个引起的反向散射和荧光光谱（约300-至900nm）。 然后通过将结果与从具有各种年龄的正常人体透镜的参考组获得的类似测量数据库进行比较，将所得到的各个透镜的光学特征用于评估镜片的整体光学质量。 已经确定了几个衡量给定镜片的光学质量相对于受试者年龄的规范的指标。 这些指标还可用于记录加速光老化和/或作为白内障或其他疾病过程的早期指标。