公开(公告)号：US4140790A

公开(公告)日：1979-02-20

申请号：US859928

申请日：1977-12-12

申请人： Karoly Felfoldi ,  Jozsef Apjok ,  Mihaly Bartok ,  Jozsef Czombos ,  Arpad Molnar ,  Ferenc Noteisz ,  Egon Karpati ,  Laszlo Szporny

发明人： Karoly Felfoldi ,  Jozsef Apjok ,  Mihaly Bartok ,  Jozsef Czombos ,  Arpad Molnar ,  Ferenc Noteisz ,  Egon Karpati ,  Laszlo Szporny

IPC分类号： C07D243/26 ,  A61K31/495 ,  A61K31/55 ,  A61K31/551 ,  A61P3/00 ,  A61P9/06 ,  A61P9/08 ,  A61P25/20 ,  C07D241/04 ,  C07D243/16 ,  C07D243/18 ,  C07D243/24 ,  C07D295/08 ,  C07D295/088 ,  C07D295/096 ,  C07D307/68 ,  C07D311/82 ,  C07D311/84 ,  C07D405/12 ,  C07D295/14 ,  C07D241/06 ,  C07D241/10

CPC分类号： C07D295/088 ,  C07D307/68 ,  C07D311/84 ,  Y10S514/821

摘要： The invention relates to novel piperazine derivatives having the formula (I), ##STR1## wherein R.sub.1 represents a C.sub.1-5 alkyl group having optionally a phenyl, trimethoxyphenyl, phenoxy, methoxy-cyclohexyl or heptamethyleneimino substituent on the terminal carbon atom, allyl group, a phenyl group having optionally one or more halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trihalomethyl or allyl substituent(s), or a C.sub.2-5 alkoxycarbonyl group,R.sub.2 represents hydrogen or a C.sub.1-4 alkyl group, andR.sub.3 represents furyl group, 9-xanthenyl group or a C.sub.5-6 cycloalkyl group having a C.sub.1-4 alkoxy substituent,Or acid addition salts or quaternary salts thereof.The invention also relates to pharmaceutical compositions containing the above compounds, furthermore to a process for the preparation of the novel compounds and pharmaceutical compositions.The novel compounds according to the invention possess anti-arrhythmic and coronary dilatating effects.The novel compounds can be prepared by reacting a compound of the formula (II) ##STR2## with a compound of the formula (III),R.sup.3 --COOH (III)or a reactive derivative thereof.

摘要翻译： 本发明涉及具有式（I）的新型哌嗪衍生物，其中R 1表示在末端碳原子上具有任选的苯基，三甲氧基苯基，苯氧基，甲氧基 - 环己基或七亚甲基亚氨基取代基的C 1-5烷基， 烯丙基，任选具有一个或多个卤素的苯基，C 1-4烷基，C 1-4烷氧基，三卤代甲基或烯丙基取代基，或C 2-5烷氧基羰基，R 2表示氢或C 1-4烷基， R3表示呋喃基，9-呫吨基或具有C1-4烷氧基取代基的C5-6环烷基，或其酸加成盐或季铵盐。

公开(公告)号：US4250310A

公开(公告)日：1981-02-10

申请号：US974082

申请日：1978-12-28

申请人： Karoly Felfoldi ,  Jozsef Apjok ,  Mihaly Bartok ,  Jozsef Czombos ,  Arpad Molnar ,  Ferenc Noteisz ,  Egon Karpati ,  Laszlo Szporny

发明人： Karoly Felfoldi ,  Jozsef Apjok ,  Mihaly Bartok ,  Jozsef Czombos ,  Arpad Molnar ,  Ferenc Noteisz ,  Egon Karpati ,  Laszlo Szporny

IPC分类号： C07D243/26 ,  A61K31/495 ,  A61K31/55 ,  A61K31/551 ,  A61P3/00 ,  A61P9/06 ,  A61P9/08 ,  A61P25/20 ,  C07D241/04 ,  C07D243/16 ,  C07D243/18 ,  C07D243/24 ,  C07D295/08 ,  C07D295/088 ,  C07D295/096 ,  C07D307/68 ,  C07D311/82 ,  C07D311/84 ,  C07D405/12

CPC分类号： C07D295/088 ,  C07D307/68 ,  C07D311/84 ,  Y10S514/821

摘要： Piperazine derivatives having the formula (I) ##STR1## wherein R.sub.1 is C.sub.1-5 alkyl group which can have a phenyl, trimethoxyphenyl, phenoxy, methoxy-cyclohexyl or heptamethyleneimino substituent on the terminal carbon atom, allyl, phenyl which can have one or more halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trihalomethyl or allyl substituents, or C.sub.2-5 alkoxycarbonyl;R.sub.2 is hydrogen or C.sub.1-4 alkyl; andR.sub.3 is furyl or a C.sub.5-6 cycloalkyl having a C.sub.1-4 alkoxy substituent, and acid addition salts or quaternary salts thereof with anti-arrhythmic and coronary dilatating pharmaceutical effects.

摘要翻译： 具有式（I）的哌嗪衍生物（I）其中R 1是可以在末端碳原子上具有苯基，三甲氧基苯基，苯氧基，甲氧基 - 环己基或七亚甲基亚氨基取代基的C1-5烷基，烯丙基，可具有 一个或多个卤素，C 1-4烷基，C 1-4烷氧基，三卤代甲基或烯丙基取代基，或C 2-5烷氧基羰基; R2是氢或C1-4烷基; R3为呋喃基或具有C1-4烷氧基取代基的C5-6环烷基，及其具有抗心律不齐和冠状动脉扩张药物作用的酸加成盐或季盐。