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1.发明申请17ALPHA-SUBSTITUTED STEROIDS AS SYSTEMIC ANTIANDROGENS AND SELECTIVE ANDROGEN RECEPTOR MODULATORS 有权作为系统性抗体和选择性受体调节剂的17ALPHA-替代的甾体公开(公告)号：US20090042844A1
公开(公告)日：2009-02-12
申请号：US12100372
申请日：2008-04-09
申请人： Fernand LABRIE , Sylvain GAUTHIER , Julie CLOUTIER , Josee MAILHOT , Steeves POTVIN , Sylvain DION , Jean-Yves SANCEAU
发明人： Fernand LABRIE , Sylvain GAUTHIER , Julie CLOUTIER , Josee MAILHOT , Steeves POTVIN , Sylvain DION , Jean-Yves SANCEAU
CPC分类号： C07J41/0094 , C07J43/003 , C07J63/008
摘要： Compounds having the structure, their salts or N-oxide derivatives: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Combinations with other active pharmaceutical agents are also disclosed.
摘要翻译： 具有结构，其盐或N-氧化物衍生物的化合物用于治疗或减少获得雄激素依赖性疾病的可能性，例如前列腺癌，良性前列腺增生症，多囊卵巢综合征，痤疮，多毛症，皮脂溢，雄激素性脱发，以及 男性秃发。 它们可以与药学上可接受的稀释剂或载体一起配制或以其它方式制成任何药物剂型。 还公开了与其它活性药剂的组合。
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2.发明授权17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators 有权17α-取代的类固醇作为系统性抗雄激素和选择性雄激素受体调节剂公开(公告)号：US09284345B2
公开(公告)日：2016-03-15
申请号：US12100372
申请日：2008-04-09
申请人： Fernand Labrie , Sylvain Gauthier , Julie Cloutier , Josée Mailhot , Steeves Potvin , Sylvain Dion , Jean-Yves Sancéau
发明人： Fernand Labrie , Sylvain Gauthier , Julie Cloutier , Josée Mailhot , Steeves Potvin , Sylvain Dion , Jean-Yves Sancéau
CPC分类号： C07J41/0094 , C07J43/003 , C07J63/008
摘要： Compounds having the structure, their salts or N-oxide derivatives: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Combinations with other active pharmaceutical agents are also disclosed.
摘要翻译： 具有结构，其盐或N-氧化物衍生物的化合物用于治疗或减少获得雄激素依赖性疾病的可能性，例如前列腺癌，良性前列腺增生症，多囊卵巢综合征，痤疮，多毛症，皮脂溢，雄激素性脱发，以及 男性秃发。 它们可以与药学上可接受的稀释剂或载体一起配制或以其它方式制成任何药物剂型。 还公开了与其它活性药剂的组合。
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