公开(公告)号：US20050129752A1

公开(公告)日：2005-06-16

申请号：US10957027

申请日：2004-10-01

Applicant: Te-Jung Chen ,  Sze-Yuan Yang ,  Chia-Ning Liu ,  Chun-Ying Huang ,  Jung-Chin Lin

Inventor： Te-Jung Chen ,  Sze-Yuan Yang ,  Chia-Ning Liu ,  Chun-Ying Huang ,  Jung-Chin Lin

IPC: A61K9/127 ,  A61K31/4745 ,  A61K31/704

CPC classification number: A61K9/1271 ,  A61K9/127 ,  A61K31/4745 ,  A61K31/704 ,  A61K47/6911

Abstract: The present invention provides a method of treating mammals having pancreatic cancer by administering a liposomal doxorubicin pharmaceutical composition, and a process of manufacturing the composition.

Abstract translation: 本发明提供了通过施用脂质体多柔比星药物组合物来治疗具有胰腺癌的哺乳动物的方法，以及制备该组合物的方法。

公开(公告)号：US07285630B2

公开(公告)日：2007-10-23

申请号：US10201501

申请日：2002-07-22

Applicant: Kiron M. Das ,  Jim Jung-Chin Lin

Inventor： Kiron M. Das ,  Jim Jung-Chin Lin

IPC: C07K14/00

CPC classification number: C07K14/4716 ,  A61K38/00 ,  C07K14/4713

Abstract: A novel isoform of tropomyosin is disclosed. The isoform is closely related to epithelial human tropomyosin (hTM) and more particularly to hTM5 except the last coding exon. The novel isoform, is called TC22. Northern blot analysis with TC22-specific probe revealed that normal culture cell lines and normal epithelial tissues expressed very little, if at all, TC22 message, whereas their transformed counterparts and tumor tissues including dysfunction of the alimentary canal, significantly increased the expression of TC22. Assays directed at determining the level of TC22 are useful in diagnostics and therapeutics of dysfunction of the alimentary canal. Specific antibodies and mimics for TC22 are also disclosed for use in diagnostics and therapeutics of dysfunction of the alimentary canal.

Abstract translation: 公开了原肌球蛋白的新型同工型。 该同种型与上皮人原肌球蛋白（hTM）密切相关，更具体地涉及除了最后编码外显子之外的hTM5。 该新型异构体称为TC22。 TC22特异性探针的Northern印迹分析显示，正常培养细胞系和正常上皮组织表达很少（如果有的话）TC22信息，而其转化的对应物和包括消化道功能障碍的肿瘤组织显着增加TC22的表达。 用于确定TC22水平的测定法可用于消化道功能障碍的诊断和治疗。 还公开了TC22的特异性抗体和模拟物用于消化道功能障碍的诊断和治疗。