公开(公告)号：US20110184388A1

公开(公告)日：2011-07-28

申请号：US13058656

申请日：2008-12-30

申请人： Suk Ho Park ,  Jong Oh Park ,  Jung Joon Min ,  Yeong Jin Hong ,  Dong Il Cho ,  Jong Mo Seo ,  Jennifer Hyunjong Shin ,  Heung Soo Shin ,  Jung Yul Park

发明人： Suk Ho Park ,  Jong Oh Park ,  Jung Joon Min ,  Yeong Jin Hong ,  Dong Il Cho ,  Jong Mo Seo ,  Jennifer Hyunjong Shin ,  Heung Soo Shin ,  Jung Yul Park

IPC分类号： A61M37/00

CPC分类号： A61B5/073 ,  A61M5/14276 ,  A61M31/002

摘要： Provided are a bacterium-based microrobot for medical treatment, an operation method thereof, and a treatment method using the same. The bacterium-based microrobot can be propelled by the flagellum movement of bacteria, can be directed toward a target lesion by the ability of bacteria to recognize the lesion, can be monitored for how many the microrobot targets the lesion, and can directly or indirectly treat the lesion by the proliferation of bacteria through self-division in the lesion. The bacteria may be genetically manipulated to be resistant to immune responses and produce a material inhibitory of the growth of affected cells.

摘要翻译： 本发明提供一种用于医疗的细菌微型机器人，其操作方法以及使用其的处理方法。 基于细菌的微型机器人可以通过细菌的鞭毛运动来推动，可以通过细菌识别病变的能力来指向目标病变，可以监测微型靶区靶点的数量，并且可以直接或间接地治疗 病变由细菌的扩散通过自我分裂的病变。 细菌可以被遗传操作以抵抗免疫应答并产生抑制受影响细胞生长的物质。

公开(公告)号：US09339018B2

公开(公告)日：2016-05-17

申请号：US13322637

申请日：2010-05-27

申请人： Hyon El Choy ,  Jung-Joon Min ,  Hyung Seok Kim ,  Yeongjin Hong

发明人： Hyon El Choy ,  Jung-Joon Min ,  Hyung Seok Kim ,  Yeongjin Hong

IPC分类号： A61K48/00 ,  A61K35/74 ,  A61K49/00 ,  A01K67/027 ,  C07K14/255 ,  A61K35/00

CPC分类号： A01K67/027 ,  A01K2207/12 ,  A01K2227/105 ,  A01K2267/0375 ,  A61K48/0033 ,  A61K2035/11 ,  C07K14/255 ,  C12N2830/001

摘要： The present invention relates to bacteria which specifically target infarcted tissue and use thereof. The present invention provides a selective infarcted tissue-targeting bacterium for the first time, and can be used in selectively delivering drugs to the infarcted tissue or in selectively imaging the infarcted tissue. The infarcted tissue-targeting bacterium of the present invention can finish treatments by using antibiotics, and therefore, have remarkable advantages as compared to gene therapy using recombinant viruses. The infarcted tissue-targeting bacterium of the present invention have a significantly high affinity and specificity to infarcted myocardium or infarcted brain, thereby significantly reducing undesired transfections in the organs or tissues other than the heart. The gene expression by the infarcted tissue-targeting bacterium of the present invention in infarcted myocardium or infarcted brain is remotely controllable.

摘要翻译： 本发明涉及特异性靶向梗死组织的细菌及其应用。 本发明首次提供了选择性梗塞的组织靶向细菌，并且可以用于选择性地将药物递送至梗死组织或选择性地成像梗塞组织。 本发明的梗塞组织靶向细菌可以通过使用抗生素来完成治疗，因此与使用重组病毒的基因治疗相比具有显着的优点。 本发明的梗死组织靶向细菌对梗塞的心肌或梗死的脑具有显着高的亲和性和特异性，从而显着减少心脏以外的器官或组织中不期望的转染。 本发明的梗死组织靶向细菌在梗死心肌或梗死的脑中的基因表达是可远程控制的。

公开(公告)号：US20120128594A1

公开(公告)日：2012-05-24

申请号：US13322637

申请日：2010-05-27

申请人： Hyon El Choy ,  Jung-Joon Min ,  Hyung Seok Kim ,  Yeongjin Hong

发明人： Hyon El Choy ,  Jung-Joon Min ,  Hyung Seok Kim ,  Yeongjin Hong

IPC分类号： A61K49/06 ,  A61P9/00 ,  A61K49/00 ,  A61P25/00 ,  A61K35/74 ,  A61K48/00

CPC分类号： A01K67/027 ,  A01K2207/12 ,  A01K2227/105 ,  A01K2267/0375 ,  A61K48/0033 ,  A61K2035/11 ,  C07K14/255 ,  C12N2830/001

摘要： The present invention relates to bacteria which specifically target infracted tissue and use thereof. The present invention provides a selective infracted tissue-targeting bacterium for the first time, and can be used in selectively delivering drugs to the infracted tissue or in selectively imaging the infracted tissue. The infracted tissue-targeting bacterium of the present invention can finish treatments by using antibiotics, and therefore, have remarkable advantages as compared to gene therapy using recombinant viruses. The infracted tissue-targeting bacterium of the present invention have a significantly high affinity and specificity to infracted myocardium or infracted brain, thereby significantly reducing undesired transfections in the organs or tissues other than the heart. The gene expression by the infracted tissue-targeting bacterium of the present invention in infracted myocardium or infracted brain is remotely controllable.

摘要翻译： 本发明涉及特异性靶向不规则组织的细菌及其应用。 本发明首次提供选择性致力于组织靶向的选择性细菌，并且可用于选择性地将药物递送至侵入组织或选择性地成像损伤的组织。 本发明的致命组织靶向细菌可以通过使用抗生素来完成治疗，因此与使用重组病毒的基因治疗相比具有显着的优点。 本发明的致伤组织靶向细菌对于心肌梗死或脑损伤具有显着高的亲和性和特异性，从而显着减少心脏以外的脏器或组织中的不期望的转染。 本发明的致伤组织靶向细菌在减毒心肌或不规则脑中的基因表达是可远程控制的。