公开(公告)号：US20110243917A1

公开(公告)日：2011-10-06

申请号：US12851137

申请日：2010-08-05

Applicant: Eunji Cheong ,  Hee-Sup Shin ,  Yihong Zheng ,  Kyoobin Lee ,  Jungryun Lee ,  Seongwook Kim ,  Maryam Sanati ,  Sukyung Lee ,  Yeon-Soo Kim

Inventor： Eunji Cheong ,  Hee-Sup Shin ,  Yihong Zheng ,  Kyoobin Lee ,  Jungryun Lee ,  Seongwook Kim ,  Maryam Sanati ,  Sukyung Lee ,  Yeon-Soo Kim

IPC: A61K38/48 ,  A61K31/215 ,  A61K31/404 ,  A61K31/575 ,  A61K31/37 ,  A61K31/23 ,  A61K31/365 ,  A61K31/357 ,  A61K31/41 ,  A61P25/08

CPC classification number: A61K31/215 ,  A61K31/23 ,  A61K31/357 ,  A61K31/365 ,  A61K31/37 ,  A61K31/404 ,  A61K31/41 ,  A61K31/575 ,  A61K38/4833

Abstract: The present invention relates to a composition comprising PKC agonist as an active ingredient. More precisely, the present inventors confirmed that absence seizure specific SWD was reduced by administrating PKC agonist into an animal model. Therefore, the composition of the present invention comprising PKC agonist as an active ingredient can be effectively used for the prevention and treatment of absence seizure and for the production of health improving functional food.

Abstract translation: 本发明涉及包含PKC激动剂作为活性成分的组合物。 更准确地说，本发明人证实，通过将PKC激动剂施用到动物模型中，不存在发作特异性SWD被降低。 因此，包含PKC激动剂作为活性成分的本发明的组合物可以有效地用于预防和治疗不发作和用于生产健康改善功能性食物。

公开(公告)号：US20080015163A1

公开(公告)日：2008-01-17

申请号：US11782771

申请日：2007-07-25

Applicant: Hee-Sup Shin ,  Daesoo Kim ,  Jungryun Lee ,  Soonwook Choi ,  Chanki Kim ,  Sukchan Lee

Inventor： Hee-Sup Shin ,  Daesoo Kim ,  Jungryun Lee ,  Soonwook Choi ,  Chanki Kim ,  Sukchan Lee

IPC: A61K48/00

CPC classification number: C12N15/8509 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03

Abstract: The present invention relates to a novel use of an α1G T-type calcium channel transgenic mouse as a nervous disease model, more particularly, a novel use of a mouse deficient in α1G T-type calcium channel showing novelty-seeking and alcohol preference as a nervous disease model for human nervous related diseases such as novelty-seeking character, alcoholism, anxiety and emotion disorder by stress, etc. The α1G T-type channel transgenic mice showing novelty-seeking and alcohol preference of the present invention can be effectively used for the development of a medicine and a therapeutic method for human nervous diseases.

Abstract translation: 本发明涉及一种α1GT型钙通道转基因小鼠作为神经疾病模型的新用途，更具体地说，一种新型使用缺乏α1GT型钙通道的小鼠，其显示出新奇寻味和酒精偏爱 针对人类神经相关疾病的神经疾病模型，如新奇寻求性格，酒精中毒，焦虑和紧张情绪障碍等。本发明显示新奇寻味和酒精偏爱的α1GT型通道转基因小鼠可有效地用于 药物的开发和人类神经疾病的治疗方法。

公开(公告)号：US20170295534A1

公开(公告)日：2017-10-12

申请号：US15364873

申请日：2016-11-30

Applicant: Myounghun HAN ,  Bongsoo ROH ,  Mijeong HOH ,  Chanyi PARK ,  Hyungseok CHOI ,  Jungryun LEE ,  Hyunho CHOI ,  Jiyoung JUNG ,  Youngjae KIM ,  Eutteum KONG ,  Uiseong YU

Inventor： Myounghun HAN ,  Bongsoo ROH ,  Mijeong HOH ,  Chanyi PARK ,  Hyungseok CHOI ,  Jungryun LEE ,  Hyunho CHOI ,  Jiyoung JUNG ,  Youngjae KIM ,  Eutteum KONG ,  Uiseong YU

IPC: H04W40/12 ,  H04L12/729 ,  H04B17/318

CPC classification number: H04W40/12 ,  H04W40/26

Abstract: Provided is a Weighted DESYNC based cross-layered resource allocation method. The method includes, with respect to each of a plurality of nodes constituting a routing path, calculating a link quality value with the next node, receiving a link quality value from at least one neighbor node, and based on the link quality values in the calculating of the link quality value and the receiving of the link quality value, calculating a weight factor for synchronizing a transmission yield.

公开(公告)号：US20090126031A1

公开(公告)日：2009-05-14

申请号：US12351316

申请日：2009-01-09

Applicant: Hee-Sup Shin ,  Daesoo Kim ,  Jungryun Lee ,  Soonwook Choi ,  Chanki Kim ,  Sukchan Lee

Inventor： Hee-Sup Shin ,  Daesoo Kim ,  Jungryun Lee ,  Soonwook Choi ,  Chanki Kim ,  Sukchan Lee

IPC: A01K67/027

CPC classification number: C12N15/8509 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03

Abstract: The present invention relates to a novel use of an α1G T-type calcium channel transgenic mouse as a nervous disease model, more particularly, a novel use of a mouse deficient in α1G T-type calcium channel showing novelty-seeking and alcohol preference as a nervous disease model for human nervous related diseases such as novelty-seeking character, alcoholism, anxiety and emotion disorder by stress, etc. The α1G T-type channel transgenic mice showing novelty-seeking and alcohol preference of the present invention can be effectively used for the development of a medicine and a therapeutic method for human nervous diseases.

Abstract translation: 本发明涉及一种α1GT型钙通道转基因小鼠作为神经疾病模型的新用途，更具体地说，一种新型使用缺乏α1GT型钙通道的小鼠，其显示出新奇寻味和酒精偏爱 针对人类神经相关疾病的神经疾病模型，如新奇寻求性格，酒精中毒，焦虑和紧张情绪障碍等。本发明显示新奇寻味和酒精偏爱的α1GT型通道转基因小鼠可有效地用于 药物的开发和人类神经疾病的治疗方法。

公开(公告)号：US08313744B2

公开(公告)日：2012-11-20

申请号：US12851137

申请日：2010-08-05

Applicant: Eunji Cheong ,  Hee-Sup Shin ,  Yihong Zheng ,  Kyoobin Lee ,  Jungryun Lee ,  Seongwook Kim ,  Maryam Sanati ,  Sukyung Lee ,  Yeon-Soo Kim ,  Sukchan Lee

Inventor： Eunji Cheong ,  Hee-Sup Shin ,  Yihong Zheng ,  Kyoobin Lee ,  Jungryun Lee ,  Seongwook Kim ,  Maryam Sanati ,  Sukyung Lee ,  Yeon-Soo Kim ,  Sukchan Lee

IPC: A61K38/48 ,  A61K31/21 ,  A61K31/12 ,  A61K31/045 ,  A61K31/015 ,  A01N37/00 ,  A01N35/00 ,  A01N31/00 ,  A01N27/00

CPC classification number: A61K31/215 ,  A61K31/23 ,  A61K31/357 ,  A61K31/365 ,  A61K31/37 ,  A61K31/404 ,  A61K31/41 ,  A61K31/575 ,  A61K38/4833

Abstract: The present invention relates to a composition comprising PKC agonist as an active ingredient. More precisely, the present inventors confirmed that absence seizure specific SWD was reduced by administrating PKC agonist into an animal model. Therefore, the composition of the present invention comprising PKC agonist as an active ingredient can be effectively used for the prevention and treatment of absence seizure and for the production of health improving functional food.

Abstract translation: 本发明涉及包含PKC激动剂作为活性成分的组合物。 更准确地说，本发明人证实，通过将PKC激动剂施用到动物模型中，不存在发作特异性SWD被降低。 因此，包含PKC激动剂作为活性成分的本发明的组合物可以有效地用于预防和治疗不发作和用于生产健康改善功能性食物。

公开(公告)号：US07723562B2

公开(公告)日：2010-05-25

申请号：US12351316

申请日：2009-01-09

Applicant: Hee-Sup Shin ,  Daesoo Kim ,  Jungryun Lee ,  Soonwook Choi ,  Chanki Kim ,  Sukchan Lee

Inventor： Hee-Sup Shin ,  Daesoo Kim ,  Jungryun Lee ,  Soonwook Choi ,  Chanki Kim ,  Sukchan Lee

IPC: A01K67/00 ,  A01K67/033 ,  A01K67/027 ,  G01N33/00

CPC classification number: C12N15/8509 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03

Abstract: The present invention relates to a novel use of an α1G T-type calcium channel transgenic mouse as a nervous disease model, more particularly, a novel use of a mouse deficient in α1G T-type calcium channel showing novelty-seeking and alcohol preference as a nervous disease model for human nervous related diseases such as novelty-seeking character, alcoholism, anxiety and emotion disorder by stress, etc. The α1G T-type channel transgenic mice showing novelty-seeking and alcohol preference of the present invention can be effectively used for the development of a medicine and a therapeutic method for human nervous diseases.

Abstract translation: 本发明涉及α1GT型钙通道转基因小鼠作为神经疾病模型的新用途，更具体地说，一种新型使用的缺乏α1GT型钙通道的小鼠，其显示新颖性和酒精偏爱为 用于人类神经相关疾病的神经疾病模型，如新奇寻求性格，酒精中毒，焦虑和紧张情绪障碍等。本发明显示新奇寻味和酒精偏爱的α1GT型通道转基因小鼠可有效地用于 药物的开发和人类神经疾病的治疗方法。

公开(公告)号：US20050251874A1

公开(公告)日：2005-11-10

申请号：US10971976

申请日：2004-10-22

Applicant: Hee-Sup Shin ,  Daesoo Kim ,  Jungryun Lee ,  Soonwook Choi ,  Chanki Kim ,  Sukchan Lee

Inventor： Hee-Sup Shin ,  Daesoo Kim ,  Jungryun Lee ,  Soonwook Choi ,  Chanki Kim ,  Sukchan Lee

IPC: A01K67/027 ,  C12N15/85

CPC classification number: C12N15/8509 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03

Abstract: The present invention relates to a novel use of an α1G T-type calcium channel transgenic mouse as a nervous disease model, more particularly, a novel use of a mouse deficient in α1G T-type calcium channel showing novelty-seeking and alcohol preference as a nervous disease model for human nervous related diseases such as novelty-seeking character, alcoholism, anxiety and emotion disorder by stress, etc. The α1G T-type channel transgenic mice showing novelty-seeking and alcohol preference of the present invention can be effectively used for the development of a medicine and a therapeutic method for human nervous diseases.

Abstract translation: 本发明涉及一种α1GT型钙通道转基因小鼠作为神经疾病模型的新用途，更具体地说，一种新型使用缺乏α1GT型钙通道的小鼠，其显示出新奇寻味和酒精偏爱 针对人类神经相关疾病的神经疾病模型，如新奇寻求性格，酒精中毒，焦虑和紧张情绪障碍等。本发明显示新奇寻味和酒精偏爱的α1GT型通道转基因小鼠可有效地用于 药物的开发和人类神经疾病的治疗方法。