公开(公告)号：US20100151038A1

公开(公告)日：2010-06-17

申请号：US12595627

申请日：2008-02-28

申请人： Tim D . Cabelka ,  Akshay Bellare ,  Ka Chun A. Chan ,  Tina P. Dasbach ,  Kacee B. Ender ,  Karl V. Jacob ,  Robert E. Scheid, JR.

发明人： Tim D . Cabelka ,  Akshay Bellare ,  Ka Chun A. Chan ,  Tina P. Dasbach ,  Kacee B. Ender ,  Karl V. Jacob ,  Robert E. Scheid, JR.

IPC分类号： A61K9/14 ,  C08B1/00 ,  A61K47/38

CPC分类号： A61K9/1652 ,  A61K31/138 ,  A61K31/55 ,  Y10T428/2982

摘要： A granular material which has a mean particle diameter of 150 to 800 micrometers; and an unsettled bulk density of 0.1 to 0.35 g/cm3 and/or a compactibility which results in a compact with a tensile strength of at least 1.7 MPa when the granular material is subjected to a compaction pressure of 266 MPa; and wherein the main component of the granular material is a cellulose derivative or an alkylene oxide homo- or copolymer or a blend thereof is useful for preparing dosage forms with a controlled release profile.

摘要翻译： 平均粒径为150〜800微米的粒状材料; 并且当颗粒材料经受266MPa的压实压力时，未稳定的堆积密度为0.1至0.35g / cm 3和/或致密度，其导致抗拉强度至少为1.7MPa的致密性; 并且其中所述颗粒材料的主要组分是纤维素衍生物或烯化氧均聚物或共聚物或其共混物可用于制备具有受控释放曲线的剂型。

公开(公告)号：US08877249B2

公开(公告)日：2014-11-04

申请号：US12595627

申请日：2008-02-28

申请人： Tim D. Cabelka ,  Akshay Bellare ,  Ka Chun A. Chan ,  Tina P. Dasbach ,  Kacee B. Ender ,  Karl V. Jacob ,  Robert E. Scheid, Jr.

发明人： Tim D. Cabelka ,  Akshay Bellare ,  Ka Chun A. Chan ,  Tina P. Dasbach ,  Kacee B. Ender ,  Karl V. Jacob ,  Robert E. Scheid, Jr.

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K9/20 ,  A61K9/26

CPC分类号： A61K9/1652 ,  A61K31/138 ,  A61K31/55 ,  Y10T428/2982

摘要： A dosage form for controlled release is produced from a composition comprising a granular material having a mean particle diameter of 150 to 350 micrometers and a compactibility resulting in a compact with a tensile strength of at least 1.7 MPa when the granular material is subjected to a compaction pressure of 266 MPa, at least 80 percent of the granular material being a water-soluble cellulose ether, water-soluble cellulose ester, an alkylene oxide homo- or copolymer, or a blend thereof; and an active ingredient.

摘要翻译： 用于控制释放的剂型由包含平均粒径为150至350微米的颗粒材料的组合物和当颗粒材料经受压实时具有至少1.7MPa的拉伸强度的紧凑性的组合物制备 266MPa的压力，至少80％的颗粒材料是水溶性纤维素醚，水溶性纤维素酯，烯化氧均聚物或共聚物或其共混物; 和活性成分。