公开(公告)号：US09221790B2

公开(公告)日：2015-12-29

申请号：US13641867

申请日：2011-04-18

Applicant: Soon-Hoe Kim ,  Weon-Bin Im ,  Sung-Hak Choi ,  Sun-Ho Choi ,  Ju-Hee Sohn ,  Hyun-Jung Sung ,  Mi-Yeon Kim ,  Kang-Hun Cho ,  Tae-Kyoung Sohn

Inventor： Soon-Hoe Kim ,  Weon-Bin Im ,  Sung-Hak Choi ,  Sun-Ho Choi ,  Ju-Hee Sohn ,  Hyun-Jung Sung ,  Mi-Yeon Kim ,  Kang-Hun Cho ,  Tae-Kyoung Sohn

IPC: C07D211/26 ,  C07D401/06

CPC classification number: C07D401/06 ,  C07D211/26

Abstract: The present invention provides a novel benzamide derivative or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a 5-HT4 receptor agonist containing the same as an active ingredient. Benzamide derivatives of the present invention have a superior affinity for 5-HT4 receptors, a capability to reduce a gastric emptying time and a low toxicity, and consequently are therapeutically effective for the treatment of a variety of diseases associated with 5-HT4 receptors.

Abstract translation: 本发明提供了一种新的苯甲酰胺衍生物或其药学上可接受的盐，其制备方法和含有该活性成分的5-HT 4受体激动剂。 本发明的苯甲酰胺衍生物对5-HT 4受体具有优异的亲和力，降低胃排空时间和低毒性的能力，因此对于治疗与5-HT 4受体相关的各种疾病具有治疗上的有效性。

公开(公告)号：US20130085160A1

公开(公告)日：2013-04-04

申请号：US13641867

申请日：2011-04-18

Applicant: Soon-Hoe Kim ,  Weon-Bin Im ,  Sung-Hak Choi ,  Sun-Ho Choi ,  Ju-Hee Sohn ,  Hyun-Jung Sung ,  Mi-Yeon Kim ,  Kang-Hun Cho ,  Tae-Kyoung Sohn

Inventor： Soon-Hoe Kim ,  Weon-Bin Im ,  Sung-Hak Choi ,  Sun-Ho Choi ,  Ju-Hee Sohn ,  Hyun-Jung Sung ,  Mi-Yeon Kim ,  Kang-Hun Cho ,  Tae-Kyoung Sohn

IPC: C07D401/06 ,  C07D211/26

CPC classification number: C07D401/06 ,  C07D211/26

Abstract: The present invention provides a novel benzamide derivative or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a 5-HT4 receptor agonist containing the same as an active ingredient. Benzamide derivatives of the present invention have a superior affinity for 5-HT4 receptors, a capability to reduce a gastric emptying time and a low toxicity, and consequently are therapeutically effective for the treatment of a variety of diseases associated with 5-HT4 receptors.

Abstract translation: 本发明提供了一种新的苯甲酰胺衍生物或其药学上可接受的盐，其制备方法和含有该活性成分的5-HT 4受体激动剂。 本发明的苯甲酰胺衍生物对5-HT 4受体具有优异的亲和力，降低胃排空时间和低毒性的能力，因此对于治疗与5-HT 4受体相关的各种疾病具有治疗上的有效性。