公开(公告)号：US06680323B2

公开(公告)日：2004-01-20

申请号：US09873746

申请日：2001-06-04

申请人： Donghui Cui ,  Margaret R. Davis ,  Michael Dunn ,  Ben E. Evans ,  Hanumath P. Kari ,  Bharat Lagu ,  Dhanapalan Nagarathnam ,  Kamlesh P. Vyas ,  Kanyin Zhang

发明人： Donghui Cui ,  Margaret R. Davis ,  Michael Dunn ,  Ben E. Evans ,  Hanumath P. Kari ,  Bharat Lagu ,  Dhanapalan Nagarathnam ,  Kamlesh P. Vyas ,  Kanyin Zhang

IPC分类号： A61K31513

CPC分类号： C07D239/22 ,  C07D401/12 ,  C07D401/14 ,  C07D491/04

摘要： This invention is directed to dihydropyrimidines which are selective antagonists for human &agr;1a receptors. This invention is also related to uses of these compounds for relaxing lower urinary tract tissue, treating benign prostatic hyperplasia and for the treatment of any disease where the antagonism of the &agr;1a receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

公开(公告)号：US20050112033A1

公开(公告)日：2005-05-26

申请号：US10934646

申请日：2004-09-03

申请人： Kanyin Zhang ,  Douglas Evans

发明人： Kanyin Zhang ,  Douglas Evans

IPC分类号： B01D61/18 ,  B01D61/28 ,  B01D61/46 ,  B01L3/00

CPC分类号： B01L3/50255 ,  B01D61/18 ,  B01D61/28 ,  B01D61/46 ,  B01L3/50855 ,  B01L2200/028

摘要： The invention provides multi-well containers that include membranes for performing various processes, including analytical and synthetic processes. Related systems, kits, and methods are also provided.

摘要翻译： 本发明提供了多孔容器，其包括用于执行各种方法的膜，包括分析和合成方法。 还提供了相关系统，套件和方法。

公开(公告)号：US06274585B1

公开(公告)日：2001-08-14

申请号：US09470691

申请日：1999-12-23

申请人： Donghui Cui ,  Margaret R. Davis ,  Michael Dunn ,  Ben E. Evans ,  Hanumath P. Kari ,  Bharat Lagu ,  Dhanapalan Nagarathnam ,  Kamlesh P. Vyas ,  Kanyin Zhang

发明人： Donghui Cui ,  Margaret R. Davis ,  Michael Dunn ,  Ben E. Evans ,  Hanumath P. Kari ,  Bharat Lagu ,  Dhanapalan Nagarathnam ,  Kamlesh P. Vyas ,  Kanyin Zhang

IPC分类号： A61K31513

CPC分类号： C07D239/22 ,  C07D401/12 ,  C07D401/14 ,  C07D491/04

摘要： This invention is directed to dihydropyrimidines which are selective antagonists for human &agr;1a receptors. This invention is also related to uses of these compounds for relaxing lower urinary tract tissue, treating benign prostatic hyperplasia and for the treatment of any disease where the antagonism of the &agr;1a receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

摘要翻译： 本发明涉及作为人α1a受体的选择性拮抗剂的二氢嘧啶。 本发明还涉及这些化合物用于缓解下尿路组织，治疗良性前列腺增生和用于治疗α1a受体的拮抗作用可能有用的任何疾病的用途。 本发明还提供了包含治疗有效量的上述化合物和药学上可接受的载体的药物组合物。