公开(公告)号：US20140072986A1

公开(公告)日：2014-03-13

申请号：US14000190

申请日：2012-02-20

申请人： Kazunori Ikebukuro ,  Kaori Tsukakoshi ,  Koji Sode

发明人： Kazunori Ikebukuro ,  Kaori Tsukakoshi ,  Koji Sode

IPC分类号： C12N15/115 ,  G01N33/68

CPC分类号： C12N15/115 ,  C12N2310/16 ,  C12N2310/50 ,  G01N33/6896

摘要： An aptamer having a G-quartet structure and being at least one selected from the group consisting of the following polynucleotides, the aptamer having a binding ability to an amyloid protein oligomer: (1) a polynucleotide comprising a base sequence represented by any one of SEQ ID NO:1 to SEQ ID NO:18; (2) a polynucleotide comprising a base sequence that includes at least four sets of at least two consecutive guanosine nucleotides and in which one or several bases has been deleted, substituted, or added in a base sequence represented by any one of SEQ ID NO:18; and (3) a polynucleotide that is a multimer including the polynucleotide of (1) or (2) as a structural unit.

摘要翻译： 具有G-四重结构并且选自下列多核苷酸中的至少一种的适体，所述适配体具有与淀粉样蛋白寡聚物的结合能力：（1）包含由SEQ ID NO： SEQ ID NO：1至SEQ ID NO：18; （2）包含碱基序列的多核苷酸，其包含至少两组至少两个连续的鸟苷核苷酸，并且其中一个或几个碱基已被缺失，取代或加入到由SEQ ID NO： 18; 和（3）多核苷酸，其是包含作为结构单元的（1）或（2）的多核苷酸的多聚体。

公开(公告)号：US09238816B2

公开(公告)日：2016-01-19

申请号：US14000190

申请日：2012-02-20

申请人： Kazunori Ikebukuro ,  Kaori Tsukakoshi ,  Koji Sode

发明人： Kazunori Ikebukuro ,  Kaori Tsukakoshi ,  Koji Sode

IPC分类号： C12N15/115 ,  G01N33/68

CPC分类号： C12N15/115 ,  C12N2310/16 ,  C12N2310/50 ,  G01N33/6896

摘要： An aptamer having a G-quartet structure and being at least one selected from the group consisting of the following polynucleotides, the aptamer having a binding ability to an amyloid protein oligomer: (1) a polynucleotide comprising a base sequence represented by any one of SEQ ID NO:1 to SEQ ID NO:18; (2) a polynucleotide comprising a base sequence that includes at least four sets of at least two consecutive guanosine nucleotides and in which one or several bases has been deleted, substituted, or added in a base sequence represented by any one of SEQ ID NO:18; and (3) a polynucleotide that is a multimer including the polynucleotide of (1) or (2) as a structural unit.

摘要翻译： 具有G-四重结构并且选自下列多核苷酸中的至少一种的适体，所述适配体具有与淀粉样蛋白寡聚物的结合能力：（1）包含由SEQ ID NO： SEQ ID NO：1至SEQ ID NO：18; （2）包含碱基序列的多核苷酸，其包含至少两组至少两个连续的鸟苷核苷酸，并且其中一个或几个碱基已被缺失，取代或加入到由SEQ ID NO： 18; 和（3）多核苷酸，其是包含作为结构单元的（1）或（2）的多核苷酸的多聚体。