公开(公告)号：US06653494B2

公开(公告)日：2003-11-25

申请号：US10210922

申请日：2002-08-02

申请人： Padiyath Mohammed Akbarali ,  Kuniyil Kulangara Vijay Raj ,  Karabasana T. Gouda ,  Ramachandran Radhakrishnan

发明人： Padiyath Mohammed Akbarali ,  Kuniyil Kulangara Vijay Raj ,  Karabasana T. Gouda ,  Ramachandran Radhakrishnan

IPC分类号： C07F902

CPC分类号： C07F9/145

摘要： A one pot process for the preparation of sterically hindered triaryl phosphite is provided. It is suitable for large scale commercial production with an advantage of having carried out the reaction at 0-5° C. in a shortest time of 1 hr using pyridine as Lewis base to remove HCl formed in the reaction; thus avoiding the usage of scrubber. The triaryl phosphite is of the formula P(OR)3 and is produced by reacting a di alkyl—substituted phenol of formula ROH with phosphorus trihalide in a presence of a Lewis base, wherein R represents an aryl compound of a formula C6H3RaRb, wherein Ra is tertiary alkyl, Rb is lower alkyl or tertiary alkyl. The process preferably comprises of mixing a stoichiometric amount of 2,4-dialkyl phenol with phosphorous trihalide in methylene chloride with different stoichiometric amounts of pyridine such as the molar equivalent, 10 mol %, 20 mol % and 50 mol % more than the amount of 2,4 dialkyl phenol. The reaction is preferably carried out at 0-5° C. and takes only 1 hr for the completion, followed by a precipitation out of isopropanol.

摘要翻译： 提供了制备空间位阻亚磷酸三芳酯的一锅法。 适用于大规模商业生产，其优点是使用吡啶作为路易斯碱，在最短时间内在0-5℃下进行反应，以除去反应中形成的HCl; 从而避免了洗涤器的使用。 亚磷酸三芳酯具有式P（OR）3，其通过在路易斯碱存在下使式ROH的二烷基取代酚与三卤化磷反应制备，其中R表示式C 6 H 3 R a R b的芳基化合物，其中R a 是叔烷基，Rb是低级烷基或叔烷基。 该方法优选包括将化学计量量的2,4-二烷基苯酚与三卤化磷在二氯甲烷中混合，其中不同的化学计量量的吡啶如摩尔当量，10摩尔％，20摩尔％和50摩尔％ 2,4-二烷基苯酚。 反应优选在0-5℃进行，完成时间仅为1小时，然后用异丙醇沉淀。