公开(公告)号：US4988517A

公开(公告)日：1991-01-29

申请号：US249845

申请日：1988-09-27

申请人： Karam El-Bayoumy ,  Bandaru S. Reddy

发明人： Karam El-Bayoumy ,  Bandaru S. Reddy

IPC分类号： A61K31/095 ,  A61K31/21

CPC分类号： A61K31/21 ,  A61K31/095

摘要： It is shown that benzylselenocyanate in the diet significantly inhibits the incidence (percentage of animals with tumors) and multiplicity (number of tumors per animal) of adenocarcinomas in the colon and multiplicity of adenocarcinomas in the small intestine compared to those fed a control diet. Selenium-dependant glutathione peroxidase activity is significantly increased in kidneys and colon and small intestinal mucosae of animals fed a benzylselenocyanate diet compared to animals fed control diets. BSC in the diet is a superior inhibitor to both its sulfur analog BTC and the inorganic selenium (sodium selenite) during the initiation phase of carcinogenesis.

摘要翻译： 显示饮食中的苄基硒氰酸盐显着抑制了结肠中腺癌的发生率（肿瘤的动物百分比）和多发性（每个动物的肿瘤数）和小肠中的腺癌的多样性，与进食对照饮食相比。 与饲喂对照饮食的动物相比，饲喂苄基硒氰酸盐饮食的动物的肾脏，结肠和小肠粘膜中硒依赖性谷胱甘肽过氧化物酶活性显着增加。 饮食中的BSC在癌发生的起始阶段是硫磺类似物BTC和无机硒（亚硒酸钠）的优良抑制剂。