公开(公告)号：US20060281676A1

公开(公告)日：2006-12-14

申请号：US10570233

申请日：2004-08-04

申请人： Dieter Willbold ,  Jorg Smolinski ,  Karen Hanel ,  Michael Wolff ,  Detlev Riesner ,  Carsten Korth

发明人： Dieter Willbold ,  Jorg Smolinski ,  Karen Hanel ,  Michael Wolff ,  Detlev Riesner ,  Carsten Korth

IPC分类号： A61K38/17 ,  C07K14/47 ,  C07H21/04 ,  C12P21/06

CPC分类号： A61K38/05

摘要： The invention relates to an agent and/or pharmaceutical active ingredient and to a method for the treatment, prevention and diagnosis of TSE, and to a method for the production of an agent and/or pharmaceutical active ingredient. According to the invention, peptides and/or nucleotide sequences coding for said peptides are provided as disclosed in the sequence protocols 127 and partial sequences thereof are disclosed. Treatment or prevention of the TSE disease, for example, in humans with Jacob Creutzfeldt syndrome, kuru, Gertmann Sträussler-Scheinker syndrome and FFI (fatal familial insomnia) can be carried out with the aid of the inventive peptides. TSE diseases are also known in animals, such as Scrapie in sheep, BSE in cows and CWD in wild animals.

摘要翻译： 本发明涉及一种药剂和/或药物活性成分以及用于治疗，预防和诊断TSE的方法，以及用于制备药剂和/或药物活性成分的方法。 根据本发明，编码所述肽的肽和/或核苷酸序列如序列方案127中所公开的那样提供，并且公开了其部分序列。 借助于本发明的肽，可以进行治疗或预防例如在Jacob Creutzfeldt综合征，kuru，GertmannSträussler-Scheinker综合征和FFI（致命家族性失眠）的人中的TSE疾病。 TSE疾病在动物中也是已知的，例如羊中的Scrapie，牛中的疯牛病和野生动物中的CWD。