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公开(公告)号：US5219555A
公开(公告)日：1993-06-15
申请号：US236401
申请日：1988-08-25
申请人： Karl-Heinz Bremer , Ludwig Kuhlmann , Michael Magerstadt , Alexander Schwarz , Axel Steinstrasser
发明人： Karl-Heinz Bremer , Ludwig Kuhlmann , Michael Magerstadt , Alexander Schwarz , Axel Steinstrasser
CPC分类号： C07F13/005 , A61K51/0482 , A61K51/0497 , C07D257/02 , A61K2121/00 , A61K2123/00
摘要： The invention relates to a method for labeling substances with--in particular radioactive--technetium or rhenium isotopes with the aid of N-substituted or C-substituted macrocyclic amine derivatives of the formula I and/or II ##STR1## in which R.sup.1 -R.sup.7, Y, m, n, o, p, f, g, h, i and j have the stated meanings, and to the use of these labeled substances, especially in medical diagnosis.
摘要翻译： 本发明涉及一种借助于式I和/或II的N-取代或C取代的大环胺衍生物，特别是放射性锝或铼同位素来标记物质的方法。 哪些R1-R7，Y，m，n，o，p，f，g，h，i和j具有所述的含义，以及这些标记物质的使用，特别是在医学诊断中。
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2.发明授权Diagnostic aid containing an organ-specific substance labeled with technetium-99m 失效诊断助剂含有用锝-99m标记的器官特异性物质
公开(公告)号：US5164175A
公开(公告)日：1992-11-17
申请号：US680114
申请日：1991-04-03
CPC分类号： A61K51/1057 , A61K51/1048 , A61K51/12 , A61K2123/00
摘要： The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which an organ specific substance, or an organ-specific substance which has been pretreated or coupled to a complexing agent for technetium-99m, is mixed with [99m]-pertechnetate and a complex-stabilized reducing agent.
摘要翻译： 本发明涉及一种制备用锝-99m标记的器官特异性物质的方法，其中已经预处理或偶联至锝-99m的络合剂的器官特异性物质或器官特异性物质是 与[99m] - 高铁酸盐和复合稳定的还原剂混合。
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3.发明授权Diagnostic aid for the scintigraphic visualization of malignant tumors comprising the substance obtained from enzymatic processing of murein using hen's eggwhite lysozyme 失效包括使用母鸡蛋白溶菌酶酶解加工murein的物质的恶性肿瘤的闪烁照相可视化的诊断辅助
公开(公告)号：US4885151A
公开(公告)日：1989-12-05
申请号：US66185
申请日：1987-06-25
申请人： Erich Oberhausen , Ludwig Kuhlmann , Gerhard Seibert , Axel Steinstrasser , Hans-Joachim Schroth , Karl-Heinz Bremer
发明人： Erich Oberhausen , Ludwig Kuhlmann , Gerhard Seibert , Axel Steinstrasser , Hans-Joachim Schroth , Karl-Heinz Bremer
CPC分类号： A61K51/088 , A61K2123/00
摘要： A diagnostic aid for the scintigraphic visualization of malignant tumors which contains a radionuclide which is bonded by means of a complex-forming agent to the substance obtained by the enzymatic processing of murein with enzyme consisting essentially of hen's eggwhite lysozyme.
摘要翻译： 用于含有通过络合物形成剂与通过酶蛋白酶蛋白酶处理的酶与酶基本上由鸡蛋白溶菌酶组成的酶结合的放射性核素的恶性肿瘤的闪烁照相可视化的诊断辅助。
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4.发明授权Process for the preparation of an organ-specific substance labeled with technetium-99m 失效用锝-99m标记的器官特异性物质的制备方法
公开(公告)号：US5723102A
公开(公告)日：1998-03-03
申请号：US466259
申请日：1995-06-06
CPC分类号： A61K51/1057 , A61K51/1048 , A61K51/12 , A61K2123/00
摘要： The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which an organ-specific substance, or an organ-specific substance which has been pretreated or coupled to a complexing agent for technetium-99m, is mixed with �99m!-pertechnetate and a complex-stabilized reducing agent.
摘要翻译： 本发明涉及一种制备用锝-99m标记的器官特异性物质的方法，其中已经预处理或偶联至锝-99m的络合剂的器官特异性物质或器官特异性物质， 与[99m] - 高铁酸盐和复合稳定的还原剂混合。
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5.发明授权Process for the preparation of an organ-specific substance labeled with technetium-99m 失效用Technoumum-99M标记的有机物质的制备方法
公开(公告)号：US5116596A
公开(公告)日：1992-05-26
申请号：US427990
申请日：1989-10-27
IPC分类号： A61K39/395 , A61K51/00 , A61K51/10 , A61K51/12 , G01N33/534
CPC分类号： A61K51/12 , A61K51/1048 , A61K51/1057 , A61K2123/00 , Y10S530/866
摘要： The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which an organ-specific substance, or an organ-specific substance which has been pretreated or coupled to a complexing agent for technetium-99m, is mixed with [99m]-pertechnetate and a complex-stabilized reducing agent.
摘要翻译： 本发明涉及一种制备用锝-99m标记的器官特异性物质的方法，其中已经预处理或偶联至锝-99m的络合剂的器官特异性物质或器官特异性物质， 与[99m] - 高铁酸盐和复合稳定的还原剂混合。
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