Preparation of phytosphingosine derivative
    1.
    发明授权
    Preparation of phytosphingosine derivative 失效
    植物营养素衍生物的制备

    公开(公告)号:US5618706A

    公开(公告)日:1997-04-08

    申请号:US494850

    申请日:1995-06-26

    摘要: The invention concerns a process for preparing tetraacetylphytospingosine (TAPS) using F-60-10 mating type strain of Pichia ciferrii. Such strain is subjected to mutagenesis and the high TAPS producing strains are selected by a special procedure. These strains are grown in a fed batch mode on a non-fermentative carbon source at a temperature above 26.degree. C and the TAPS collected from the fermentation medium. Glycerol is a preferred carbon source and preferably L-serine is added to the culture medium.

    摘要翻译: 本发明涉及一种使用毕赤酵母的F-60-10交配型菌株制备四乙酰紫杉醇(TAPS)的方法。 对这种菌株进行诱变,通过特殊的方法选择高TAPS产生菌株。 这些菌株在非发酵碳源上以补料分批模式生长,温度高于26℃,从发酵培养基中收集TAPS。 甘油是优选的碳源,优选将L-丝氨酸加入到培养基中。