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公开(公告)号：US4276304A
公开(公告)日：1981-06-30
申请号：US113218
申请日：1980-01-18
IPC分类号： A61K31/13 , A61K31/135 , A61P3/08 , A61P7/02 , C07C45/28 , C07C45/64 , C07C49/82 , C07C49/84 , C07C67/00 , C07C205/32 , C07C213/00 , C07C217/60 , C07C217/70 , C07D317/58 , C07C91/34
CPC分类号： C07C205/32 , C07C45/28 , C07C45/64 , C07C49/82 , C07C49/84
摘要： A benzylalcohol derivative of the formula: ##STR1## wherein R is hydroxy, benzyloxy, alkoxy of one to 4 carbon atoms or halogen, and Ring A is monomethoxyphenyl, dimethoxyphenyl, trimethoxyphenyl or 3,4-methylenedioxyphenyl is prepared by reducing a compound of the formula: ##STR2## wherein R' is benzyloxy, alkoxy of one to 4 carbon atoms or halogen, and Ring A is the same as defined above, and when R' is benzyloxy, if required, further subjecting the product to catalytic hydrogenation.The compounds (I) and pharmaceutically acceptable acid addition salts thereof are used as anti-diabetic agents.
摘要翻译： 下式的苄醇衍生物：其中R是羟基，苄氧基，1-4个碳原子的烷氧基或卤素，A环是单甲氧基苯基，二甲氧基苯基，三甲氧基苯基或3,4-亚甲二氧基苯基。 下式的化合物：其中R'是苄氧基，1-4个碳原子的烷氧基或卤素，环A与上述相同，当R'是苄氧基时，如果需要，进一步使产物催化 氢化。 化合物（I）及其药学上可接受的酸加成盐用作抗糖尿病药。
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公开(公告)号：US4113873A
公开(公告)日：1978-09-12
申请号：US793920
申请日：1977-05-05
申请人： Junichi Himizu , Shoichi Harigaya , Shigeyoshi Saijo , Masao Wada , Katsuyuki Noguchi , Osasi Takaiti
发明人： Junichi Himizu , Shoichi Harigaya , Shigeyoshi Saijo , Masao Wada , Katsuyuki Noguchi , Osasi Takaiti
IPC分类号： C07D207/26 , A61K31/40
CPC分类号： C07D207/26
摘要： Novel 8-azaprostanoic acid derivatives and processes for preparing the same are disclosed. Said 8-azaprostanoic acid derivatives are shown by the formula: ##STR1## wherein R.sup.1 is hydrogen or alkyl of 2 to 6 carbon atoms, R.sup.2 is hydrogen or methyl and R.sup.3 is hydrogen, or R.sup.1 is methyl when R.sup.2 is hydrogen and R.sup.3 is methyl. They exhibit Prostaglandin-like activities and are useful as bronchodilators, stimulating agents for childbirth, abortion or labor, and/or for the treatment of gastro-intestinal disorders.
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