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公开(公告)号：US3936452A
公开(公告)日：1976-02-03
申请号：US479189
申请日：1974-06-13
IPC分类号： C07D207/16 , C07D209/20 , C07D239/10
CPC分类号： C07D209/20 , C07D207/16 , Y02P20/582
摘要： Thiolcarbonates represented by the formula, ##SPC1##Wherein R.sub.1 and R.sub.2 are individually a hydrogen atom or a methyl group, and R.sub.3 is a straight chain or branched chain saturated or unsaturated alkyl group having 1 to 5 carbon atoms or is a benzyl or benzhydryl group which may be nuclear substituted, are easily produced by reacting an alkali metal salt of 2-mercaptopyrimidine with phosgene, and reacting the resulting thiolchloroformate with an alcohol (R.sub.3 OH).
摘要翻译： 由式WHEREIN R1和R2表示的硫醇碳酸酯分别为氢原子或甲基，R3为具有1至5个碳原子的直链或支链饱和或不饱和烷基，或可为苄基或二苯甲基， 通过使2-巯基嘧啶的碱金属盐与光气反应，使得到的硫酸氯甲酸酯与醇（R3OH）反应容易地制备。
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2.发明授权Process for acylation of amino, imino and hydroxyl groups using pyrimidine derivatives 失效使用嘧啶衍生物酰化氨基，亚氨基和羟基的方法
公开(公告)号：US3960829A
公开(公告)日：1976-06-01
申请号：US509221
申请日：1974-09-25
IPC分类号： C07K1/08 , C07C103/52 , C07C69/00 , C07C125/00
摘要： Pyrimidine derivatives represented by the formula, ##SPC1##Wherein R.sub.1 and R.sub.2 are individually a hydrogen atom or a methyl group, and R.sub.3 is a group formed by removing the carboxyl group from a carboxylic acid, are quite useful in acylating compounds having amino and/or imino and/or hydroxyl groups. The pyrimidine derivatives can easily be prepared by reacting a 2-mercapto-4- and/or 6-methyl-substituted or unsubstituted pyrimidine with a carboxylic acid or a reactive derivative thereof in an inert solvent.
摘要翻译： 由式WHEREIN R1和R2表示的嘧啶衍生物分别为氢原子或甲基，R3为通过从羧酸除去羧基而形成的基团，在酰化具有氨基和/或亚氨基的化合物和 /或羟基。 嘧啶衍生物可以容易地通过使2-巯基-4-和/或6-甲基取代或未取代的嘧啶与羧酸或其活性衍生物在惰性溶剂中反应来制备。
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3.发明授权Use of 2-pyrimidine thiol carbonates as acylating agents for amino or imino containing compounds 失效使用2-嘧啶硫醇碳酸酯作为氨基或亚氨基化合物的酰化剂
公开(公告)号：US3932375A
公开(公告)日：1976-01-13
申请号：US479188
申请日：1974-06-13
IPC分类号： C07D209/20 , C07C103/52
CPC分类号： C07D209/20 , Y02P20/582
摘要： Thiolcarbonates represented by the formula, ##SPC1##Wherein R.sub.1 and R.sub.2 are individually a hydrogen atom or a methyl group, and R.sub.3 is a straight chain or branched chain saturated or unsaturated alkyl group having 1 to 5 carbon atoms or is a benzyl or benzhydryl group which may be nuclear substituted, are quite useful for protecting the amino or imino groups of amines, hydrazines, amino acids and peptides with groups of the formula ##EQU1## The thiolcarbonates can be easily produced by reacting an alkali metal salt of 2-mercaptopyrimidine with phosgene, and reacting the resulting thiolchloroformate with an alcohol (R.sub.3 OH), or by reacting a 2-mercaptopyrimidine with a halocarbonic acid ester.
摘要翻译： 由式WHEREIN R1和R2表示的硫醇碳酸酯分别为氢原子或甲基，R3为具有1至5个碳原子的直链或支链饱和或不饱和烷基，或可为苄基或二苯甲基， 核取代对于保护胺，氨，氨基酸和肽的氨基或亚胺基与式O-PARALLEL-CO-R3基团相当有用。
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