公开(公告)号：US06548284B1

公开(公告)日：2003-04-15

申请号：US09704611

申请日：2000-11-03

申请人： Masafumi Matsuo ,  Koji Ikeda ,  Noriaki Emoto ,  Sunu Budhi Raharjo ,  Yudha Nurhantari ,  Kayoko Saiki ,  Mitsuhiro Yokoyama

发明人： Masafumi Matsuo ,  Koji Ikeda ,  Noriaki Emoto ,  Sunu Budhi Raharjo ,  Yudha Nurhantari ,  Kayoko Saiki ,  Mitsuhiro Yokoyama

IPC分类号： C12N964

CPC分类号： C12N9/6489

摘要： Disclosed are metalloprotease proteins or their salts usable for treatment or prophylaxis of conformational diseases and for providing a screening kit for selection of carcinostatics and anti-metastatic agents. The metalloprotease proteins have an amino acid sequence set forth under SEQ ID NO:1 or NO:2 in the Sequence Listing. The proteins have a neutral optimal pH, hydrolyze endothelin 1, atrial natriuretic peptide and angiotensin I and are inhibited by 1,10-phenanthroline, phosphoramidon and thiorphan.

摘要翻译： 公开了可用于治疗或预防构象疾病的金属蛋白酶蛋白或其盐，并提供用于选择制癌和抗转移剂的筛选试剂盒。 金属蛋白酶蛋白质具有序列表中SEQ ID NO：1或NO：2所示的氨基酸序列。 蛋白质具有中性最佳pH，水解内皮素1，心房钠尿肽和血管紧张素I，并被1,10-菲咯啉，磷酰胺和噻唑烷抑制。