公开(公告)号：US06923987B2

公开(公告)日：2005-08-02

申请号：US09963570

申请日：2001-09-27

申请人： Toshiya Kai ,  Kazuyuki Yamamoto ,  Kazutaka Fujiki ,  Makoto Sato

发明人： Toshiya Kai ,  Kazuyuki Yamamoto ,  Kazutaka Fujiki ,  Makoto Sato

IPC分类号： A61M1/14 ,  A61K9/50 ,  A61K33/14 ,  A61M1/16 ,  A61K9/14 ,  A01N59/08 ,  A61K9/00 ,  A61K9/16

CPC分类号： A61M1/1654 ,  A61K9/5084 ,  A61K33/14 ,  A61K33/00 ,  A61K31/70 ,  A61K31/19 ,  A61K2300/00

摘要： A solid preparation for dialysis for preparing a double preparation type sodium bicarbonate solid preparation for dialysis in which there is no fear that a sugar component is decomposed or colored, and which can maintain stability and is also excellent in content homogeneity and a process for producing the same. The solid preparation for dialysis is a mixture of a first composition composed of core particles including sodium chloride and a coating layer containing one or more electrolytes, a second composition composed of core particles including a sugar that is covered with a coating layer comprising the same sugar or a different sugar, and an acid.

摘要翻译： 一种用于制备用于透析的双重制备型碳酸氢钠固体制剂用于透析的固体制剂，其中不必担心糖组分分解或着色，并且其可以保持稳定性并且内容物均匀性优异，并且制备方法 相同。 用于透析的固体制剂是由包含氯化钠的核心颗粒和包含一种或多种电解质的涂层组成的第一组合物的混合物，由包含糖的核心颗粒组成的第二组合物，所述糖颗粒被包含相同糖的涂层 或不同的糖和酸。

公开(公告)号：US06407070B1

公开(公告)日：2002-06-18

申请号：US09655450

申请日：2000-09-05

申请人： Toshiya Kai ,  Kazuyuki Yamamoto ,  Kazutaka Fujiki ,  Hiroaki Kato ,  Makoto Sato

发明人： Toshiya Kai ,  Kazuyuki Yamamoto ,  Kazutaka Fujiki ,  Hiroaki Kato ,  Makoto Sato

IPC分类号： A61K3300

CPC分类号： A61K33/00 ,  A61K9/167 ,  A61K9/5084 ,  A61K31/19 ,  A61K31/7004 ,  A61K33/06 ,  A61K33/14 ,  A61M1/1654 ,  A61K2300/00

摘要： A one-pack solid pharmaceutical composition for dialysate containing sodium bicarbonate which can prevent the reactions between sodium bicarbonate and acetic acid and between sodium bicarbonate and electrolytes, and is excellent in long term storage stability is provided. The solid pharmaceutical composition for dialysate containing sodium bicarbonate is a mixture of an agent A containing sodium chloride, calcium chloride, magnesium chloride, potassium chloride, sodium acetate and acetic acid and an agent B containing sodium bicarbonate coated with sodium acetate.

摘要翻译： 提供含有碳酸氢钠的透析液的单组分固体药物组合物，其可以防止碳酸氢钠和乙酸之间以及碳酸氢钠和电解质之间的反应，并且具有优异的长期保存稳定性。 含有碳酸氢钠的透析液的固体药物组合物是含有氯化钠，氯化钙，氯化镁，氯化钾，乙酸钠和乙酸的试剂A和含有用乙酸钠包被的碳酸氢钠的试剂B的混合物。

公开(公告)号：US06464977B2

公开(公告)日：2002-10-15

申请号：US09963550

申请日：2001-09-27

申请人： Toshiya Kai ,  Kazuyuki Yamamoto ,  Kazutaka Fujiki ,  Makoto Sato

发明人： Toshiya Kai ,  Kazuyuki Yamamoto ,  Kazutaka Fujiki ,  Makoto Sato

IPC分类号： A61K39395

CPC分类号： A61K9/209

摘要： A solid preparation for dialysis for preparing a double preparation type sodium bicarbonate solid preparation for dialysis in which there is no fear that a sugar is decomposed or colored, and which can maintain stability and also is excellent in content homogeneity and a process for producing the same. The solid preparation for dialysis is a mixture of a first composition composed of core particles including sodium chloride that are coated with a coating layer containing one or more electrolytes, a second composition composed of core particles including a sugar that are covered with a coating layer containing one or more electrolytes, and an acid.

摘要翻译： 一种用于制备用于透析的双重制备型碳酸氢钠固体制剂用于透析的固体制剂，其中不必担心糖分解或着色，并且其可以保持稳定性并且还具有优异的含量均匀性及其制备方法 。 透析固体制剂是由包含氯化钠的核心颗粒组成的第一组合物，涂覆有包含一种或多种电解质的涂层的第二组合物，由包含糖的核心颗粒组成的第二组合物，该第二组合物被覆盖有包含 一种或多种电解质和酸。