公开(公告)号：US20090326259A1

公开(公告)日：2009-12-31

申请号：US12308364

申请日：2007-06-13

申请人： Hideki Ushio ,  Reiko Nagasaka ,  Kazuyuki Ohhara ,  Hiroshi Ozaki ,  Masatoshi Hori

发明人： Hideki Ushio ,  Reiko Nagasaka ,  Kazuyuki Ohhara ,  Hiroshi Ozaki ,  Masatoshi Hori

IPC分类号： C07C69/76

CPC分类号： A61K31/56 ,  A61K31/575 ,  C07J9/00 ,  C07J53/00

摘要： The object is to provide a highly safe NF-κB activation inhibitor at a low cost which can be used for prevention and treatment of diseases associated with the activation of NF-κB such as inflammation or type-2 diabetes. Specifically, the NF-κB activation inhibitor comprises a compound represented by the chemical structural formula depicted in the following Chemical Formula 1 [wherein R1 represents a hydroxy group; R2 represents a hydroxy group, a methoxy group or an alkoxy group; and R3 represents an ester comprising triterpene or a salt thereof] or a salt of the compound as active ingredient. A representative example of the compound is hydroxycinnamic acid derivative triterpene alcohol ester.

摘要翻译： 目的是以低成本提供高度安全的NF-κB活化抑制剂，其可用于预防和治疗与NF-κB活化相关的疾病如炎症或2型糖尿病。 具体地说，NF-κB激活抑制剂包含由下列化学式1所示的化学结构式表示的化合物[其中R1表示羟基; R2表示羟基，甲氧基或烷氧基; R3表示包含三萜烯或其盐的酯]或该化合物的盐作为活性成分。 该化合物的代表性实例是羟基肉桂酸衍生物三萜醇酯。