公开(公告)号：US20060030050A1

公开(公告)日：2006-02-09

申请号：US11196212

申请日：2005-08-03

申请人： Ken Milne ,  Margaret Lawlor

发明人： Ken Milne ,  Margaret Lawlor

IPC分类号： G01N33/72

CPC分类号： G01N33/6842 ,  G01N33/54313 ,  G01N33/68 ,  G01N33/6893 ,  G01N33/723 ,  G01N2800/042 ,  G01N2800/22

摘要： Compositions and assay methods for and relating to the detection of glycated hemoglobin are provided. In particular, the presence and level of glycated hemoglobin can be detected in a blood sample. The compositions comprise microparticles which have zinc coating for use in the improved binding of proteins exhibiting a zinc binding domain, in particular glycated hemoglobin.

公开(公告)号：US20110263042A1

公开(公告)日：2011-10-27

申请号：US12918416

申请日：2009-02-20

申请人： Ken Milne ,  David Pritchard ,  Erling Sundrehagen

发明人： Ken Milne ,  David Pritchard ,  Erling Sundrehagen

IPC分类号： G01N33/566 ,  C07K2/00 ,  B82Y15/00

CPC分类号： G01N33/564 ,  G01N2800/102

摘要： The present invention relates to method for assaying anti-cyclic citrullinated peptide antibodies in a clinical sample, said method comprising contacting said sample with at least one homogeneous reagent comprising at least one specific binder for anti-CCP antibodies, whereby to form a solution or suspension of an anti-CCP-binding partner complex in a homogeneous sample mixture and detecting the presence or level of said anti-CCP-binding partner complex in a homogeneous liquid-phase. The invention also relates to a method for the assessment of the existence of; risk of; potential for; or propensity to RA in a subject.

摘要翻译： 本发明涉及用于在临床样品中测定抗环瓜氨酸肽抗体的方法，所述方法包括使所述样品与包含至少一种特异性粘合剂的至少一种均质试剂接触以用于抗CCP抗体，从而形成溶液或悬浮液 在均匀样品混合物中的抗CCP-结合配偶体复合物，并检测在均相液相中所述抗CCP-结合配偶体复合物的存在或水平。 本发明还涉及一种评估存在的方法; 风险; 潜力 或倾向RA。

公开(公告)号：US07592182B2

公开(公告)日：2009-09-22

申请号：US11196212

申请日：2005-08-03

申请人： Ken Milne ,  Margaret Lawlor

发明人： Ken Milne ,  Margaret Lawlor

IPC分类号： G01N33/72 ,  G01N33/558

CPC分类号： G01N33/6842 ,  G01N33/54313 ,  G01N33/68 ,  G01N33/6893 ,  G01N33/723 ,  G01N2800/042 ,  G01N2800/22

摘要： Compositions and assay methods for and relating to the detection of glycated hemoglobin are provided. In particular, the presence and level of glycated hemoglobin can be detected in a blood sample. The compositions comprise microparticles which have zinc coating for use in the improved binding of proteins exhibiting a zinc binding domain, in particular glycated hemoglobin.

摘要翻译： 提供了糖基化血红蛋白检测的组成和检测方法。 特别地，可以在血液样品中检测糖化血红蛋白的存在和水平。 组合物包含具有锌涂层的微粒，其用于改善结合显示锌结合结构域的蛋白质，特别是糖化血红蛋白。