公开(公告)号：US20050281866A1

公开(公告)日：2005-12-22

申请号：US11136328

申请日：2005-05-23

申请人： Peter Jarrett ,  Kenneth Messier ,  Robert Miller ,  C. Philbrook ,  Hildegard Kramer ,  J. Kablik ,  Erika Johnston ,  Luis Avila ,  Arthur Coury

发明人： Peter Jarrett ,  Kenneth Messier ,  Robert Miller ,  C. Philbrook ,  Hildegard Kramer ,  J. Kablik ,  Erika Johnston ,  Luis Avila ,  Arthur Coury

IPC分类号： A61L15/16 ,  A61L24/00 ,  A61L24/04 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10

CPC分类号： A61L31/06 ,  A61L24/0042 ,  A61L24/043 ,  A61L27/34 ,  A61L31/10 ,  C08L71/02

摘要： Described herein are adhesive polymeric compositions and methods for using the compositions. The composition are adherent to the applied surface. The compositions, in certain embodiments, are biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications. The adherent polymeric compositions comprise a polymerized macromer network and an additive mixed or entangled in the polymerized macromer. The additive is bonded to a surface by at least one covalent bond or by secondary interactions and is not covalently bonded to the polymerized macromer network. Alternatively, the additive is bonded to the surface by at least one covalent bond and is also bonded to the macromer network. The disclosed compositions can be used as an improved barrier, coating or drug delivery system that due to the additive is highly adherent to an applied surface. The compositions of the present invention are typically non-toxic, water miscible and have adaptable characteristics depending on the macromers and additives used. For example, specific macromers can be used for targeted bioresorption rate and/or degradation rate of the applied composition.

摘要翻译： 本文描述的是粘合聚合物组合物和使用该组合物的方法。 组合物附着在所施加的表面上。 在某些实施方案中，组合物是可生物降解的和生物相容的，并且可以设计成具有针对不同手术和治疗应用的选择性的适应性和弹性。 粘附的聚合物组合物包含聚合的大分子单体网络和在聚合的大分子单体中混合或缠结的添加剂。 添加剂通过至少一个共价键或通过二次相互作用结合到表面上，并且不共价键合到聚合的大分子单体网络上。 或者，添加剂通过至少一个共价键与表面键合，并且也结合到大分子单体网络上。 所公开的组合物可以用作改进的屏障，涂层或药物递送系统，由于添加剂与施加的表面高度粘附。 根据所使用的大分子单体和添加剂，本发明的组合物通常是无毒的，水可混溶的并具有适应性的特性。 例如，特定的大分子单体可用于所应用组合物的靶向生物再吸收速率和/或降解速率。