-
公开(公告)号：US20090118256A1
公开(公告)日：2009-05-07
申请号：US11952343
申请日：2007-12-07
IPC分类号： A61K31/554 , A61P9/10
CPC分类号： A61K31/55 , A61K9/2081 , A61K9/4866 , A61K9/5031 , A61K9/5047
摘要： A method of treating or preventing myocardial ischemia in a patient in need thereof comprising administration of a controlled-release Galenical preparation of pharmaceutically acceptable Diltiazem including the pharmaceutically acceptable salts thereof, suitable for evening dosing every 24 hours containing from about 180 mg to about 420 mg of the form of Diltiazem associated with excipients to provide controlled (sustained) release of the form of Diltiazem for providing a Cmax of diltiazem in the blood at between about 10 hours and about 17 hours after administration, the preparation comprising the form of Diltiazem in oral sustained-release dosage form in which the Diltiazem is adapted to be released after administration over a prolonged period of time and exhibits when given to humans (i) a higher bioavailability when given at night compared to when given in the morning without food according to FDA guidelines or criteria and (ii) bioequivalence when given in the morning with and without food according to the same FDA guidelines or criteria.
摘要翻译： 一种在有需要的患者中治疗或预防心肌缺血的方法，包括施用药学上可接受的地尔硫卓的可释放的Galenical制剂，包括其药学上可接受的盐，适合于每24小时进行晚间给药，其含有约180mg至约420mg 与给药相关的地尔硫卓形式，以提供受控（持续）的地尔硫卓形式的释放，用于在给药后约10小时至约17小时之间在血液中提供地塞米松的C max，所述制剂包含口服的地尔硫卓形式 持续释放剂型，其中地尔硫卓适于在长时间给药后释放，并在给予人时显示（i）当晚上给予时，与根据FDA没有食物的早晨相比，具有较高的生物利用度 准则或标准，以及（ii）早晨给予的机智的生物等效性 根据相同的FDA指导方针或标准，可以获得食物。
-
公开(公告)号：US07348028B2
公开(公告)日：2008-03-25
申请号：US10657752
申请日：2003-09-09
CPC分类号： A61K31/55 , A61K9/2081 , A61K9/4866 , A61K9/5031 , A61K9/5047
摘要： A method of treating or preventing myocardial ischemia in a patient in need thereof comprising administration of a controlled-release Galenical preparation of pharmaceutically acceptable Diltiazem including the pharmaceutically acceptable salts thereof, suitable for evening dosing every 24 hours containing from about 180 mg to about 420 mg of the form of Diltiazem associated with excipients to provide controlled (sustained) release of the form of Diltiazem for providing a Cmax of Diltiazem in the blood at between about 10 hours and about 17 hours after administration, the preparation comprising the form of Diltiazem in oral sustained-release dosage form in which the Diltiazem is adapted to be released after administration over a prolonged period of time and exhibits when given to humans(i) a higher bioavailability when given at night compared to when given in the morning without food according to FDA guidelines or criteria and(ii) bioequivalence when given in the morning with and without food according to the same FDA guidelines or criteria.
摘要翻译： 一种在有需要的患者中治疗或预防心肌缺血的方法，包括施用药学上可接受的地尔硫卓的可释放的Galenical制剂，包括其药学上可接受的盐，适合于每24小时进行晚间给药，其含有约180mg至约420mg 与给药相关的地尔硫卓形式，以提供受控（持续）释放的地尔硫卓形式，用于在给药后约10小时至约17小时之间在血液中提供地尔硫卓的最大值， 包含地尔硫卓口服持续释放剂型形式的制剂，其中地尔硫卓适于在长时间给药后释放，并在给予人时显示（i）与给予时相比较，在晚上给予时具有较高的生物利用度 在早晨没有食物根据FDA指导方针或标准，和（ii）生物等效性在早晨w给予 根据相同的FDA指南或标准，不含食物。
-
公开(公告)号：US07108866B1
公开(公告)日：2006-09-19
申请号：US09567451
申请日：2000-05-08
CPC分类号： A61K9/5042 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K31/55
摘要： A controlled-release Galenical preparation of pharmaceutically acceptable Diltiazem including the pharmaceutically acceptable salts thereof, suitable for evening dosing every 24 hours containing from about 120 mg to about 540 mg or more (as desired) of the form of Diltiazem associated with excipients to provide controlled (sustained) release of the form of Diltiazem for providing a Cmax of Diltiazem in the blood at between about 10 hours and about 15 hours after administration, the preparation comprising the form of Diltiazem in oral sustained-release dosage form in which the Diltiazem is adapted to be released after administration over a prolonged period of time and exhibits when given to humans(i) a higher bioavailability when given at night compared to when given in the morning without food according to FDA guidelines or criteria and(ii) bioequivalence when given in the morning with and without food according to the same FDA guidelines or criteria.
-
-
搜索结果
3 条记录 (耗时 0.019 秒)
