COMBINATION THERAPY OF HSP90 INHIBITORY COMPOUNDS WITH RADIOTHERAPY
    1.
    发明申请
    COMBINATION THERAPY OF HSP90 INHIBITORY COMPOUNDS WITH RADIOTHERAPY 审中-公开
    HSP90抑制化合物与放射治疗的联合治疗

    公开(公告)号:US20140051664A1

    公开(公告)日:2014-02-20

    申请号:US14001039

    申请日:2012-02-22

    摘要: Methods for treating cancer in a subject, comprising administering to the subject an effective amount of a compound represented by the following structural formula a tautomer, or a pharmaceutically acceptable salt thereof in combination with radiotherapy. The variables depicted in the structural formula are defined herein.

    摘要翻译: 用于治疗受试者中的癌症的方法,包括向受试者施用有效量的由以下结构式表示的化合物与放射治疗组合的互变异构体或其药学上可接受的盐。 结构式中描述的变量在本文中定义。

    HSP90 INHIBITORY COMPOUNDS IN TREATING JAK/STAT SIGNALING-MEDIATED CANCERS
    2.
    发明申请
    HSP90 INHIBITORY COMPOUNDS IN TREATING JAK/STAT SIGNALING-MEDIATED CANCERS 审中-公开
    HSP90抑制剂治疗JAK / STAT信号传导癌的化合物

    公开(公告)号:US20140045908A1

    公开(公告)日:2014-02-13

    申请号:US14001427

    申请日:2012-02-24

    IPC分类号: A61K31/4196

    CPC分类号: A61K31/4196 A61K31/675

    摘要: Methods for treating a subject with cancer mediated through dysregulated, aberrant, or defective JAK/STAT signaling, are provided, comprising determining the level of the JAK/STAT signaling in a sample derived from a subject in need of treatment, wherein the presence of dysregulated, aberrant, or defective JAK/STAT signaling is indicated, administering to the subject an effective amount of a triazolone compound as described herein.

    摘要翻译: 提供了通过失调的,异常的或有缺陷的JAK / STAT信号传导介导的患有癌症的受试者的方法,包括确定衍生自需要治疗的受试者的样品中JAK / STAT信号的水平,其中存在失调 ,表示异常或缺陷的JAK / STAT信号传导,向受试者施用有效量的本文所述的三唑酮化合物。

    Stethoscope having pseudostereophonic binaural enhancement
    4.
    发明授权
    Stethoscope having pseudostereophonic binaural enhancement 失效
    听诊器具有伪立体声双耳增强

    公开(公告)号:US4783814A

    公开(公告)日:1988-11-08

    申请号:US917160

    申请日:1986-10-09

    申请人: Kevin P. Foley

    发明人: Kevin P. Foley

    IPC分类号: A61B7/04

    CPC分类号: A61B7/04

    摘要: A stethoscope having a monophonic electrical sensor which feeds electrical signals corresponding to heart sounds to a transversal filter to produce pseudostereophonic signals at split outputs which may be used to power dual earphones for binaural listening. The electronic processing of the heart sounds in the transversal filter enables the listener to differentiate the different sounds of the heart.

    摘要翻译: 具有单声道电传感器的听诊器,其将对应于心脏声音的电信号馈送到横向滤波器以在分离输出处产生伪立体声信号,其可用于为双耳机供电进行双耳听音。 在横向滤波器中,心脏的电子处理声音使听众区分不同的心脏声音。