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公开(公告)号：US07569285B2
公开(公告)日：2009-08-04
申请号：US10179743
申请日：2002-06-24
申请人： Jeffrey Schwartz , Michael P. Danahy , Michael J. Avaltroni , Kim S. Midwood , Jean E. Schwarzbauer , Michael D. Carolus , Ellen S. Gawalt
发明人： Jeffrey Schwartz , Michael P. Danahy , Michael J. Avaltroni , Kim S. Midwood , Jean E. Schwarzbauer , Michael D. Carolus , Ellen S. Gawalt
CPC分类号： B05D1/185 , B82Y30/00 , B82Y40/00 , C23C14/06 , Y10T428/12556 , Y10T428/1259 , Y10T428/1266 , Y10T428/12806
摘要： The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.
摘要翻译： 本发明提供在材料的天然氧化物表面上的致密覆盖的粘附的磷基涂层。 公开的磷基涂层包括磷酸盐和有机膦酸盐涂层。 本发明还提供了磷基涂层的进一步衍生化，以在钛材料的天然氧化物表面上产生化学反应性涂层和成骨细胞粘附促进和增殖促进涂层的致密表面覆盖。
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公开(公告)号：US08092585B2
公开(公告)日：2012-01-10
申请号：US12907823
申请日：2010-10-19
IPC分类号： C09K17/02
摘要： The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.
摘要翻译： 本发明提供在材料的天然氧化物表面上的致密覆盖的粘附的磷基涂层。 公开的磷基涂层包括磷酸盐和有机膦酸盐涂层。 本发明还提供了磷基涂层的进一步衍生化，以在钛材料的天然氧化物表面上产生化学反应性涂层和成骨细胞粘附促进和增殖促进涂层的致密表面覆盖。
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公开(公告)号：US07815963B2
公开(公告)日：2010-10-19
申请号：US12115067
申请日：2008-05-05
IPC分类号： A61L6/083
摘要： The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.
摘要翻译： 本发明提供在材料的天然氧化物表面上的致密覆盖的粘附的磷基涂层。 公开的磷基涂层包括磷酸盐和有机膦酸盐涂层。 本发明还提供了磷基涂层的进一步衍生化，以在钛材料的天然氧化物表面上产生化学反应性涂层和成骨细胞粘附促进和增殖促进涂层的致密表面覆盖。
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公开(公告)号：US20080206443A1
公开(公告)日：2008-08-28
申请号：US12115067
申请日：2008-05-05
申请人： Jeffrey Schwartz , Michael J. Avaltroni , Kim S. Midwood , Jean E. Schwarzbauer , Ellen S. Gawalt
发明人： Jeffrey Schwartz , Michael J. Avaltroni , Kim S. Midwood , Jean E. Schwarzbauer , Ellen S. Gawalt
摘要： The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.
摘要翻译： 本发明提供在材料的天然氧化物表面上的致密覆盖的粘附的磷基涂层。 公开的磷基涂层包括磷酸盐和有机膦酸盐涂层。 本发明还提供了磷基涂层的进一步衍生化，以在钛材料的天然氧化物表面上产生化学反应性涂层和成骨细胞粘附促进和增殖促进涂层的致密表面覆盖。
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公开(公告)号：US08758899B2
公开(公告)日：2014-06-24
申请号：US13238900
申请日：2011-09-21
IPC分类号： C09D1/00
摘要： The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osetoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.
摘要翻译： 本发明提供在材料的天然氧化物表面上的致密覆盖的粘附的磷基涂层。 公开的磷基涂层包括磷酸盐和有机膦酸盐涂层。 本发明还提供了磷基涂层的进一步衍生化，以在钛材料的天然氧化物表面上产生化学反应性涂层和成骨细胞附着促进和增殖促进涂层的致密表面覆盖。
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公开(公告)号：US20120012033A1
公开(公告)日：2012-01-19
申请号：US13238900
申请日：2011-09-21
IPC分类号： C09D1/00
摘要： The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osetoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.
摘要翻译： 本发明提供在材料的天然氧化物表面上的致密覆盖的粘附的磷基涂层。 公开的磷基涂层包括磷酸盐和有机膦酸盐涂层。 本发明还提供了磷基涂层的进一步衍生化，以在钛材料的天然氧化物表面上产生化学反应性涂层和成骨细胞附着促进和增殖促进涂层的致密表面覆盖。
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公开(公告)号：US20110093082A1
公开(公告)日：2011-04-21
申请号：US12907823
申请日：2010-10-19
摘要： The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osetoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.
摘要翻译： 本发明提供在材料的天然氧化物表面上的致密覆盖的粘附的磷基涂层。 公开的磷基涂层包括磷酸盐和有机膦酸盐涂层。 本发明还提供了磷基涂层的进一步衍生化，以在钛材料的天然氧化物表面上产生化学反应性涂层和成骨细胞附着促进和增殖促进涂层的致密表面覆盖。
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公开(公告)号：US07507483B2
公开(公告)日：2009-03-24
申请号：US10405557
申请日：2003-04-01
申请人： Jeffrey Schwartz , Michael J. Avaltroni , Michael D. Carolus , Eric L. Hanson , Jean E. Schwarzbauer , Kim S. Midwood , Michael P. Danahy
发明人： Jeffrey Schwartz , Michael J. Avaltroni , Michael D. Carolus , Eric L. Hanson , Jean E. Schwarzbauer , Kim S. Midwood , Michael P. Danahy
CPC分类号： B05D1/185 , B82Y30/00 , B82Y40/00 , C23C14/06 , Y10T428/12556 , Y10T428/1259 , Y10T428/1266 , Y10T428/12806
摘要： An implantable device with a metal, metal alloy, metalloid, polymeric or ceramic surface and a phosphonic acid coating layer directly contacting the surface wherein the surface has hydroxyl groups covalently bonded to the acid groups of the coating layer and the phosphonate organic ligands are omega-functionalized.
摘要翻译： 具有金属，金属合金，准金属，聚合物或陶瓷表面的可植入装置和直接接触表面的膦酸涂层，其中表面具有共价键合到涂层和膦酸酯有机配体的酸基上的羟基是ω- 功能化。
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