公开(公告)号：US5266719A

公开(公告)日：1993-11-30

申请号：US885766

申请日：1992-05-20

申请人： Shinichi Kishimoto ,  Kimiyasu Sakamoto ,  So Abe ,  Toshihisa Kato

发明人： Shinichi Kishimoto ,  Kimiyasu Sakamoto ,  So Abe ,  Toshihisa Kato

IPC分类号： C07K1/02 ,  C07K1/14 ,  C07K5/072 ,  C07K5/075 ,  C07C229/00

CPC分类号： C07K5/0613

摘要： In neutralizing an acid addition salt of .alpha.-APM in an aqueous medium, the .alpha.-APM concentration in the neutralized liquid is controlled to fall within the range of from 3 to 10 wt. % at the finish of neutralization. Then, the liquid is heated to 50.degree. to 80.degree. C. and neutralization is effected with stirring to the isoelectric point of .alpha.-APM; or after the neutralization, the neutralized liquid is heated. The neutralized liquid is thereafter cooled with or without stirring so that crystals of .alpha.-APM are precipitated.

公开(公告)号：US5399554A

公开(公告)日：1995-03-21

申请号：US5421

申请日：1993-01-19

申请人： Kimiyasu Sakamoto ,  Toshihide Yukawa

发明人： Kimiyasu Sakamoto ,  Toshihide Yukawa

IPC分类号： A61K31/195 ,  A61K31/70 ,  A61K47/18 ,  C07D473/18 ,  A61K31/52

CPC分类号： A61K31/70 ,  A61K47/183 ,  Y10S514/964

摘要： A readily soluble 2',3'-dideoxyinosine composition is prepared by combining 80 to 1 parts by weight of a basic amino acid and 20 to 99 parts by weight of 2',3'-dideoxyinosine. The greater solution velocity of this composition improves solubility for therapeutic uses.

摘要翻译： 通过将80至1重量份的碱性氨基酸和20至99重量份的2'，3'-二脱氧肌苷组合，制备易溶的2'，3'-二脱氧肌苷组合物。 该组合物的较大的溶液速度提高了治疗用途的溶解性。